Evidence map›Paper›PMID 36959441›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Contact-Assisted Threading in Low-Homology Protein Modeling.

Sutanu Bhattacharya, Rahmatullah Roche, Md Hossain Shuvo, Bernard Moussad, Debswapna Bhattacharya

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sutanu BhattacharyaDepartment of Computer Science and Software Engineering, Auburn University, Auburn, AL, USA.
Rahmatullah RocheDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA.
Md Hossain ShuvoDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA.
Bernard MoussadDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA.
Debswapna BhattacharyaDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA. dbhattacharya@vt.edu.
Virginia Tech · USAuburn University · US

Funding

GPU-accelerated high-performance computing to supercharge foundational deep learning method development for scalable and accurate prediction of protein structuresR35GM138146 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Debswapna Bhattacharya · 2020 to 2026
$2.5M
NIGMS NIH HHS R35 GM138146
6 · The paper itself

Abstract

The ability to successfully predict the three-dimensional structure of a protein from its amino acid sequence has made considerable progress in the recent past. The progress is propelled by the improved accuracy of deep learning-based inter-residue contact map predictors coupled with the rising growth of protein sequence databases. Contact map encodes interatomic interaction information that can be exploited for highly accurate prediction of protein structures via contact map threading even for the query proteins that are not amenable to direct homology modeling. As such, contact-assisted threading has garnered considerable research effort. In this chapter, we provide an overview of existing contact-assisted threading methods while highlighting the recent advances and discussing some of the current limitations and future prospects in the application of contact-assisted threading for improving the accuracy of low-homology protein modeling.

Indexed as

AlgorithmsSequence Analysis, ProteinAmino Acid SequenceDatabases, ProteinProtein ConformationProtein FoldingProteinsSoftwareProteinsContact-assisted threadingProtein structure predictionProtein threadingResidue-residue contactTemplate-based modeling

Identifiers

PMID36959441
PMCPMC10340115
OpenAlexW4360762427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.