Evidence map›Paper›PMID 36959424›Full record

ArticleMolecular diversity2024

Design, synthesis and neuraminidase inhibitory activity of 4-methyl-5-(3-phenylacryloyl) thiazoles.

Yu-Yang Liu, Yang-Jie Yi, Jiao Ye, Ai-Xi Hu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu-Yang LiuCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Yang-Jie YiCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Jiao YeCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. yejiao@hnu.edu.cn.
Ai-Xi HuCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. axhu@hnu.edu.cn.

Funding

Changsha Natural Science Foundation kq2202183
6 · The paper itself

Abstract

A series of 4-methyl-5-(3-phenylacryloyl)thiazoles based on chalcones were designed, synthesized and evaluated for their influenza neuraminidase (NA) inhibitory activity in vitro. A preliminary structure-activity relationship (SAR) analysis showed that thiazoles bearing amide had greater potency. It also showed that mono-hydroxyl group at 4-position on phenyl ring was more effective than other electron-releasing groups or electron-withdraw groups. Compounds A2 and A26 were more potent against NA with IC

Indexed as

Drug DesignEnzyme InhibitorsMolecular Docking SimulationNeuraminidaseThiazolesAntiviral AgentsStructure-Activity RelationshipAntiviral AgentsEnzyme InhibitorsNeuraminidaseThiazoles4-Methyl-5-(3-phenylacryloyl)thiazolesMolecular dockingNeuraminidase (NA) inhibitory activity

Identifiers

PMID36959424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.