ArticleNature neuroscience2023
Ascending neurons convey behavioral state to integrative sensory and action selection brain regions.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- A neural connectivity atlas for fly flight control.Current biology : CB · 2026Article
- Drosophila DNp03 descending neurons serve as a hub within a flight saccade network.Current biology : CB · 2026Article
- Multisensory integration for active mechanosensation in Drosophila flight.Current biology : CB · 2026Article
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- Sexually-dimorphic neurons in thebioRxiv : the preprint server for biology · 2025Article
- Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg.Nature communications · 2025Article
- Statistical signature of subtle behavioral changes in large-scale assays.PLoS computational biology · 2025Article
- FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep inScience advances · 2025Article
- Connectomic analysis of taste circuits in Drosophila.Scientific reports · 2025Article
- A split-GAL4 driver line resource foreLife · 2025Article
- NeuroMechFly v2: simulating embodied sensorimotor control in adult Drosophila.Nature methods · 2024Article
- A normative framework dissociates need and motivation in hypothalamic neurons.Science advances · 2024Article
- Article
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Authors and funding
8 authors.
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Abstract
Knowing one's own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons (ANs) in the motor system that project to the brain are well positioned to provide such behavioral state signals. However, what ANs encode and where they convey these signals remains largely unknown. Here, through large-scale functional imaging in behaving animals and morphological quantification, we report the behavioral encoding and brain targeting of hundreds of genetically identifiable ANs in the adult fly, Drosophila melanogaster. We reveal that ANs encode behavioral states, specifically conveying self-motion to the anterior ventrolateral protocerebrum, an integrative sensory hub, as well as discrete actions to the gnathal ganglia, a locus for action selection. Additionally, AN projection patterns within the motor system are predictive of their encoding. Thus, ascending populations are well poised to inform distinct brain hubs of self-motion and ongoing behaviors and may provide an important substrate for computations that are required for adaptive behavior.
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