Evidence map›Paper›PMID 36959357›Full record

ArticleScientific reports2023

Machine learning at the edge for AI-enabled multiplexed pathogen detection.

Vahid Ganjalizadeh, Gopikrishnan G Meena, Matthew A Stott, Aaron R Hawkins, Holger Schmidt

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  4. "CLADE-FINDER":Microorganisms · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vahid GanjalizadehSchool of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA.ORCID 0000-0002-8768-3654
Gopikrishnan G MeenaSchool of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA.
Matthew A StottElectrical and Computer Engineering Department, Brigham Young University, Provo, UT, 84602, USA.
Aaron R HawkinsElectrical and Computer Engineering Department, Brigham Young University, Provo, UT, 84602, USA.
Holger SchmidtSchool of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA. hschmidt@soe.ucsc.edu.
University of California, Santa Cruz · USBrigham Young University · US

Funding

Multiplexed, Non-Amplified, Nucleic Acid-Based Identification of Multidrug Resistant Pathogens Using an Integrated Optofluidic PlatformR01AI116989 · NIAID · BRIGHAM YOUNG UNIVERSITY · PI HAWKINS, AARON R., PITT, WILLIAM G · 2015 to 2019
$5.4M
Nanopore-based multi-target analysis of Zika virus infectionR01EB028608 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SCHMIDT, HOLGER · 2019 to 2022
$2.7M
NIAID NIH HHS R01 AI116989NIBIB NIH HHS R01 EB028608
6 · The paper itself

Abstract

Multiplexed detection of biomarkers in real-time is crucial for sensitive and accurate diagnosis at the point of use. This scenario poses tremendous challenges for detection and identification of signals of varying shape and quality at the edge of the signal-to-noise limit. Here, we demonstrate a robust target identification scheme that utilizes a Deep Neural Network (DNN) for multiplex detection of single particles and molecular biomarkers. The model combines fast wavelet particle detection with Short-Time Fourier Transform analysis, followed by DNN identification on an AI-specific edge device (Google Coral Dev board). The approach is validated using multi-spot optical excitation of Klebsiella Pneumoniae bacterial nucleic acids flowing through an optofluidic waveguide chip that produces fluorescence signals of varying amplitude, duration, and quality. Amplification-free 3× multiplexing in real-time is demonstrated with excellent specificity, sensitivity, and a classification accuracy of 99.8%. These results show that a minimalistic DNN design optimized for mobile devices provides a robust framework for accurate pathogen detection using compact, low-cost diagnostic devices.

Indexed as

Machine LearningNucleic AcidsFluorescenceNeural Networks, ComputerNucleic Acids

Identifiers

PMID36959357
PMCPMC10034896
OpenAlexW4360619552

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read16
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.