Evidence map›Paper›PMID 36959347›Full record

ArticleScientific reports2023

Development and clinical validation of Swaasa AI platform for screening and prioritization of pulmonary TB.

Gayatri Devi Yellapu, Gowrisree Rudraraju, Narayana Rao Sripada, Baswaraj Mamidgi, Charan Jalukuru, Priyanka Firmal, Venkat Yechuri, Sowmya Varanasi, Venkata Sudhakar Peddireddi, Devi Madhavi Bhimarasetty and 4 more

Erratum issued Registry-linked trialOpen access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05989802 (Rapid Research in Diagnostics Development for Tuberculosis Network), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05989802 narecruitingnot on this mapstarted 2024, after this paper: background citation

Rapid Research in Diagnostics Development for Tuberculosis Network (R2D2 Kids) and Assessing Diagnostics At Point-of-care for Tuberculosis in Children (ADAPT for Kids)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2026Enrolled2,100ConditionsTuberculosis, Diagnostics, Global HealthArmsOral swab molecular testing, Automated Cough Sound Analysis, Automated Lung Sound Analysis, Chest X Ray Computer Aided Detection
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Cough biomarkers for diagnosis and monitoring of respiratory disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Pooled it
  3. Audio-based digital biomarkers in diagnosing and managing respiratory diseases: a systematic review and bibliometric analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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  16. Artificial Intelligence: The new weapon to END TB.Lung India : official organ of Indian Chest Society · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Gayatri Devi YellapuAndhra Medical College, Visakhapatnam, India.
Gowrisree RudrarajuSalcit Technologies, Jayabheri Silicon Towers, Hyderabad, India. gowri@salcit.in.
Narayana Rao SripadaSalcit Technologies, Jayabheri Silicon Towers, Hyderabad, India.
Baswaraj MamidgiSalcit Technologies, Jayabheri Silicon Towers, Hyderabad, India.
Charan JalukuruSalcit Technologies, Jayabheri Silicon Towers, Hyderabad, India.
Priyanka FirmalSalcit Technologies, Jayabheri Silicon Towers, Hyderabad, India.
Venkat YechuriSalcit Technologies, Jayabheri Silicon Towers, Hyderabad, India.
Sowmya VaranasiAndhra Medical College, Visakhapatnam, India.
Venkata Sudhakar PeddireddiAndhra Medical College, Visakhapatnam, India.
Devi Madhavi BhimarasettyAndhra Medical College, Visakhapatnam, India.
Sidharth KanisettiAndhra Medical College, Visakhapatnam, India.
Niranjan JoshiCentre for Cellular and Molecular Platforms, Bengaluru, India.
Prasant MohapatraDepartment of Computer Science, University of California, Davis, USA.
Kiran PamarthiAndhra Medical College, Visakhapatnam, India.
Andhra University · INCentre for Cellular and Molecular Biology · INUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acoustic signal analysis has been employed in various medical devices. However, studies involving cough sound analysis to screen the potential pulmonary tuberculosis (PTB) suspects are very few. The main objective of this cross-sectional validation study was to develop and validate the Swaasa AI platform to screen and prioritize at risk patients for PTB based on the signature cough sound as well as symptomatic information provided by the subjects. The voluntary cough sound data was collected at Andhra Medical College-India. An Algorithm based on multimodal convolutional neural network architecture and feedforward artificial neural network (tabular features) was built and validated on a total of 567 subjects, comprising 278 positive and 289 negative PTB cases. The output from these two models was combined to detect the likely presence (positive cases) of PTB. In the clinical validation phase, the AI-model was found to be 86.82% accurate in detecting the likely presence of PTB with 90.36% sensitivity and 84.67% specificity. The pilot testing of model was conducted at a peripheral health care centre, RHC Simhachalam-India on 65 presumptive PTB cases. Out of which, 15 subjects truly turned out to be PTB positive with a positive predictive value of 75%. The validation results obtained from the model are quite encouraging. This platform has the potential to fulfil the unmet need of a cost-effective PTB screening method. It works remotely, presents instantaneous results, and does not require a highly trained operator. Therefore, it could be implemented in various inaccessible, resource-poor parts of the world.

Indexed as

Mycobacterium tuberculosisTuberculosis, PulmonaryArtificial IntelligenceCoughCross-Sectional StudiesHumansSputum

Identifiers

PMID36959347
PMCPMC10034902
OpenAlexW4360613656

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read47
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.