ArticleCommunications biology2023
Recordings in an integrating central neuron reveal the mode of action of isoeugenol.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Excavating Precursors from Herb PairsPharmaceuticals (Basel, Switzerland) · 2025Article
- Modulation of Voltage-Gated Sodium Channels from Sensory Neurons by Isoeugenol.International journal of molecular sciences · 2025Article
- Assessment of the effect of tricaine (MS-222)-induced anesthesia on brain-wide neuronal activity of zebrafish (Frontiers in neuroscience · 2024Article
- The effect of eugenol anesthesia on the electric organ discharge of the weakly electric fish Apteronotus leptorhynchus.Fish physiology and biochemistry · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although isoeugenol is one of the most widely used anesthetics in fish, its actual mode of action and thus its applicability for particular interventions is poorly understood. Here we determined effects of isoeugenol on various aspects of sensory and neural function, taking advantage of intracellular in vivo recordings in a uniquely suited identified neuron, the Mauthner neuron in the brain of goldfish. We show that isoeugenol strongly affects hearing and vision, but sensitivity and time course of action differed largely in these two senses. The action potential, chemical and electric synaptic transmission at the central neuron were not affected at low but efficient anesthesia. Effects seen at high concentration thereby do not support current views of how isoeugenol might act on central neurons. We show that isoeugenol is highly useful to anesthetize fish for handling, but that in more severe treatment its application needs to be carefully adapted to task.
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Registered trials
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