ArticleNature immunology2023
How autoreactive thymocytes differentiate into regulatory versus effector CD4
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Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
- TIF1γ regulates stability of regulatory T cells during inflammation.Nature immunology · 2026Article
- Rag1-based time-stamp tracing of T-cell developmental origins.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Runx3 instructs AireJournal of autoimmunity · 2026Article
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- KLF2 controls thymic epithelial cell homeostasis, impacting regulatory T cell development and immune tolerance.iScience · 2026Article
- Unraveling CD8 lineage decisions reveals that functionally distinct CD8Nature immunology · 2026Article
- Regulatory T Cell Heterogeneity in the Steady State and Tumor.Immune network · 2026Review
- Regulatory T cells in bullous pemphigoid: biological characteristics, dysfunction, and pathogenic roles.Frontiers in immunology · 2026Review
- IgE, anti-IgE therapy, and regulatory T cells: new paradigms in allergic inflammation.Frontiers in allergy · 2026Review
- Single-cell transcriptome delineating asymmetric dynamics of CD4Frontiers in immunology · 2026Article
- Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025Review
- Impact of kynurenine metabolites on B and T cells in multiple sclerosis and allergies.IBRO neuroscience reports · 2025Review
- [Guardians of Immune Tolerance: Regulatory T Cells].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Review
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Growth of human regulatory CD4iScience · 2025Article
- High Antigenicity for TCancer science · 2025Article
- Harnessing the biology of regulatory T cells to treat disease.Nature reviews. Drug discovery · 2025Review
- PD-1 and CD73 on naive CD4Nature immunology · 2025Article
- Unlocking the therapeutic potential of thymus-isolated regulatory T cells.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 2 countries.
Xuguang TaiExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Alyssa IndartExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2662-0964
Mirelle RojanoExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jie GuoKey Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Nicolai ApenesExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Tejas KadakiaExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Marco CraveiroExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Amala AlagExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ruth EtzenspergerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mohamed Elsherif BadrExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Flora ZhangExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Zhongmei ZhangExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jie MuExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Terry GuinterExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Assiatu CrossmanExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5746-0073
Larry GrangerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Susan SharrowExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Xuyu ZhouKey Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-6626-0898
Alfred SingerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. singera@mail.nih.gov.ORCID 0000-0002-6780-5108
National Institutes of Health · USChinese Academy of Sciences · CN
Funding
MHC-independent T cellsZIABC011116 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2025
$12.3MT Cell Differentiation and Repertoire SelectionZIABC009273 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2025
$11.6MDevelopment and function of regulatory T cellsZIABC011112 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2025
$6.8MT cell survivalZIABC011113 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2023
$4.8MRole of microRNAs in T cell developmentZIABC011114 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2023
$4.8MT cell receptor regulation of cytokine signalingZIABC011117 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2023
$4.8MSpecification of T cell function during developmentZIABC011106 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2023
$4.8MCytokine signaling in developing thymocytes and T cellsZIABC011111 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2023
$4.8MAbstract
Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to differentiate into specialized regulatory T (T
Indexed as
Clonal DeletionThymocytesCD4-Positive T-LymphocytesForkhead Transcription FactorsInterleukin-2Receptors, Antigen, T-CellThymus GlandT-Lymphocytes, RegulatoryForkhead Transcription FactorsInterleukin-2Receptors, Antigen, T-Cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.