Evidence map›Paper›PMID 36959289›Full record

ArticleScientific reports2023

Pneumoproteins and biomarkers of inflammation and coagulation do not predict rapid lung function decline in people living with HIV.

David M MacDonald, Sarah Samorodnitsky, Chris H Wendt, Jason V Baker, Gary Collins, Monica Kruk, Eric F Lock, Roger Paredes, Selvamuthu Poongulali, Danielle O Weise and 4 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 20 institutions in 21 countries.

David M MacDonaldMinneapolis Veterans Affairs Health Care System, Pulmonary, Critical Care, and Sleep Apnea (111N), One Veterans Drive, Minneapolis, MN, 55417, USA. macdo147@umn.edu.
Sarah SamorodnitskyUniversity of Minnesota, Minneapolis, USA.
Chris H WendtMinneapolis Veterans Affairs Health Care System, Pulmonary, Critical Care, and Sleep Apnea (111N), One Veterans Drive, Minneapolis, MN, 55417, USA.
Jason V BakerUniversity of Minnesota, Minneapolis, USA.
Gary CollinsUniversity of Minnesota, Minneapolis, USA.
Monica KrukUniversity of Minnesota, Minneapolis, USA.
Eric F LockUniversity of Minnesota, Minneapolis, USA.
Roger ParedesHospital German Trias, Badalona, Spain.
Selvamuthu PoongulaliChennai Antiviral Research and Treatment Centre Clinical Research Site, CART-CRS-Infectious Diseases Medical Centre, VHS Chennai, Chennai, India.
Danielle O WeiseUniversity of Minnesota, Minneapolis, USA.
Alan WinstonImperial College London, London, UK.
Robin WoodDesmond Tutu Health Foundation, Cape Town, South Africa.
Ken M KunisakiMinneapolis Veterans Affairs Health Care System, Pulmonary, Critical Care, and Sleep Apnea (111N), One Veterans Drive, Minneapolis, MN, 55417, USA.
INSIGHT START Pulmonary Substudy Group
University College London · GBUniversity of Minnesota · USAsociación Civil Impacta Salud y Educación · PEFundación para la Investigación, Docencia y Prevención del Cáncer · ARDesmond Tutu HIV Foundation · ZAUNSW Sydney · AUAHEPA University Hospital · GRBelfast Health and Social Care Trust · GBBoston University · USChulalongkorn University · THFlorida Department of Health in Orange County · USHelsinki University Hospital · FIHenry Ford Health System · USHospital de Sant Pau · ESHospital Nacional Cayetano Heredia · PEMedical College of Wisconsin · USRoyal Berkshire Hospital · GBRoyal Perth Hospital · AUSiriraj Hospital · THUniversitätsklinikum Erlangen · DE

Funding

International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)UM1AI068641 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2011 to 2014
$83.5M
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT): STARTUM1AI120197 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2015 to 2017
$65.1M
TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
Effects of HIV antiretroviral therapy on pulmonary function in a randomized trialR01HL096453 · NHLBI · UNIVERSITY OF MINNESOTA · PI KUNISAKI, KEN M. · 2009 to 2017
$4.2M
Spingolipids in HIV-associated Chronic Obstructive Pulmonary DiseaseR01HL140971 · NHLBI · UNIVERSITY OF MINNESOTA · PI GRIFFIN, TIMOTHY J., KUNISAKI, KEN M. · 2018 to 2021
$2.7M
Department of HealthMedical Research CouncilNHLBI NIH HHS R01 HL096453NHLBI NIH HHS R01 HL140971NHLBI NIH HHS T32 HL007741NIAID NIH HHS UM1 AI068641NIAID NIH HHS UM1 AI120197
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is among the leading causes of death worldwide and HIV is an independent risk factor for the development of COPD. However, the etiology of this increased risk and means to identify persons with HIV (PWH) at highest risk for COPD have remained elusive. Biomarkers may reveal etiologic pathways and allow better COPD risk stratification. We performed a matched case:control study of PWH in the Strategic Timing of Antiretoviral Treatment (START) pulmonary substudy. Cases had rapid lung function decline (> 40 mL/year FEV

Indexed as

HIV InfectionsPulmonary Disease, Chronic ObstructiveBiomarkersHumansInflammationLungBiomarkers

Identifiers

PMID36959289
PMCPMC10036615
OpenAlexW4360613813

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read95
identifiers read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.