ArticleScientific reports2023
Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Ovariectomy, but not moderate intermittent hypoxia, promotes respiratory instability and risk of obesity in adult female rats.Experimental physiology · 2026Article
- Effects of regular swimming exercise on caveolin, insulin signaling, and SREBP-1c in adipose tissue of high-fat-fed ovariectomized rats.Physical activity and nutrition · 2026Article
- The plant hormone, 6-benzylaminopurine, ameliorates obesity in male and female mice while on a high-fat diet.Molecular metabolism · 2026Article
- Hyperactive basolateral amygdala mediates comorbid anxiety in chronic rhinosinusitis.Journal of neuroinflammation · 2026Article
- High-fat diet attenuates estradiol's efficacy on cognitive function and hippocampal synaptic plasticity in middle-aged ovariectomized mice.Physiological reports · 2026Article
- Congenital vs adult-onset estrogen deficiency in female mice: physiological effects and implications for therapy.The Journal of endocrinology · 2026Article
- Exogenous estradiol does not regulate daily metabolic rhythms underlying diet-induced obesity in male mice.PloS one · 2026Article
- Article
- Estrogenic Effect of Probiotics on Anxiety and Depression: A Narrative Review.International journal of molecular sciences · 2025Review
- Artificially fermented dark loose tea ameliorates metabolic-associated fatty liver disease by activating the PI3K/AKT signalling pathway and regulating gut microbiota dysbiosis.Food chemistry: X · 2025Article
- The effects of pharmacologic estradiol on anxiety-related behavior in adolescent and adult female mice.Physiology & behavior · 2025Article
- Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults.Metabolites · 2025Article
- High-fat diet impairs the dendritic morphology of hippocampal CA1 pyramidal neurons in male but not female mice.Frontiers in nutrition · 2025Article
- Microbial alpha diversity in the intestine negatively correlated with disease duration in patients with Meniere's disease.Scientific reports · 2024Article
- Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy.Nature communications · 2024Article
- Treatment with brain specific estrogen prodrug ameliorates cognitive effects of surgical menopause in mice.Hormones and behavior · 2024Article
- Conditioned overconsumption is dependent on reinforcer type in lean, but not obese, mice.Appetite · 2024Article
- The Loss of Estradiol by Androgen Deprivation in Prostate Cancer Patients Shows the Importance of Estrogens in Males.Journal of the Endocrine Society · 2024Review
- Unravelling the Crosstalk between Estrogen Deficiency and Gut-biotaDysbiosis in the Development of Diabetes Mellitus.Current diabetes reviews · 2024Review
- Influences ofFrontiers in microbiomes · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Decreased estrogens during menopause are associated with increased risk of anxiety, depression, type 2 diabetes and obesity. Similarly, depleting estrogens in rodents by ovariectomy, combined with a high-fat diet (HFD), increases anxiety and adiposity. How estrogens and diet interact to affect anxiety and metabolism is poorly understood. Mounting evidence indicates that gut microbiota influence anxiety and metabolism. Here, we investigated the effects of estradiol (E) and HFD on anxiety, metabolism, and their correlation with changes in gut microbiota in female mice. Adult C57BL/6J mice were ovariectomized, implanted with E or vehicle-containing capsules and fed a standard diet or HFD. Anxiety-like behavior was assessed and neuronal activation was measured by c-fos immunoreactivity throughout the brain using iDISCO. HFD increased anxiety-like behavior, while E reduced this HFD-dependent anxiogenic effect. Interestingly, E decreased neuronal activation in brain regions involved in anxiety and metabolism. E treatment also altered gut microbes, a subset of which were associated with anxiety-like behavior. These findings provide insight into gut microbiota-based therapies for anxiety and metabolic disorders associated with declining estrogens in menopausal women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.