Evidence map›Paper›PMID 36958537›Full record

ArticleAmerican journal of ophthalmology2023

Onset and Progression of Persistent Choroidal Hypertransmission Defects in Intermediate Age-Related Macular Degeneration: A Novel Clinical Trial Endpoint.

Jeremy Liu, Mengxi Shen, Rita Laiginhas, Gissel Herrera, Jianqing Li, Yingying Shi, Farhan Hiya, Omer Trivizki, Nadia K Waheed, Carol Y Chung and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 44 citations in OpenAlex.

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  5. Review of emerging imaging findings to reveal a broader spectrum of lesions in AMD.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jeremy LiuDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Mengxi ShenDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Rita LaiginhasDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Gissel HerreraDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Jianqing LiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Yingying ShiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Farhan HiyaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Omer TrivizkiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts (N.K.W.), USA.
Carol Y ChungCarol Chung Statistics Consulting, Inc, Pacifica, California (C.Y.C.), USA.
Eric M MoultDepartment of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts (E.M.M., J.G.F.), USA.
James G FujimotoDepartment of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts (E.M.M., J.G.F.), USA.
Giovanni GregoriDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA.
Philip J RosenfeldDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (J. Liu, M.S., R.L., G.H., J. Li, Y.S., F.H., O.T., G.G., P.J.R.), USA. Electronic address: prosenfeld@miami.edu.
University of Miami · USMassachusetts Institute of Technology · USTufts University · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dmitry V Ivanov · 2004 to 2026
$12.2M
Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY011289
6 · The paper itself

Abstract

purposeThe appearance and growth of persistent choroidal hypertransmission defects (hyperTDs) detected on en face swept-source optical coherence tomography (SS-OCT) images from eyes with intermediate age-related macular degeneration (iAMD) were studied to determine if they could serve as novel clinical trial endpoints.

designPost hoc subgroup analysis of a prospective study.

methodsSubjects with iAMD underwent 6 × 6 mm SS-OCT angiography imaging at their baseline and follow-up visits. The drusen volumes were obtained using a validated SS-OCT algorithm. Two graders independently evaluated all en face structural images for the presence of persistent hyperTDs. The number and area of all hyperTDs along with drusen volume were obtained from all SS-OCT angiography scans. Eyes were censored from further follow-up once exudative AMD developed.

resultsA total of 171 eyes from 121 patients with iAMD were included. Sixty-eight eyes developed at least 1 hyperTD. Within 1 year after developing a hyperTD, 25% of eyes developed new hyperTDs for an average of 0.44 additional hyperTDs. Over 2 years, as hyperTDs appeared, enlarged, and merged, the average area growth rate was 0.220 mm/yr using the square-root transformation strategy. A clinical trial design using the onset and enlargement of these hyperTDs for the study of disease progression in eyes with iAMD is proposed.

conclusionsThe appearance and growth of persistent choroidal hyperTDs in eyes with iAMD can be easily detected and measured using en face OCT imaging and can serve as novel clinical trial endpoints for the study of therapies that may slow disease progression from iAMD to late AMD.

Indexed as

Macular DegenerationClinical Trials as TopicDisease ProgressionFluorescein AngiographyHumansProspective StudiesRetina

Identifiers

PMID36958537
PMCPMC10514236
OpenAlexW4353050172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.