Evidence map›Paper›PMID 36958516›Full record

ArticleJournal of thrombosis and haemostasis : JTH2023

Loss of P2Y

David S Paul, Tasha N Blatt, Wyatt J Schug, Emily G Clark, Tomohiro Kawano, Nigel Mackman, Sebastian Murcia, Kathryn O Poe, Jean Marie N Mwiza, T Kendall Harden and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Advances in nucleotide-based P2Y₁ antagonism: implications for cardiovascular therapeutics.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  3. Review
  4. Article
  5. Modeling platelet P2YBiophysical journal · 2025
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

David S PaulDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: https://twitter.com/David_S_Paul.
Tasha N BlattDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wyatt J SchugDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Emily G ClarkDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tomohiro KawanoUNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nigel MackmanUNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sebastian MurciaDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kathryn O PoeDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jean Marie N MwizaDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
T Kendall HardenDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wolfgang BergmeierDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: bergmeie@email.unc.edu.
Robert A NicholasDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: nicholas@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Small GTPases in the biology of platelets and megakaryocytesR35HL144976 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERGMEIER, WOLFGANG · 2019 to 2025
$5.4M
NHLBI NIH HHS R35 HL144976
6 · The paper itself

Abstract

backgroundThe hemostatic plug formation at sites of vascular injury is strongly dependent on rapid platelet activation and integrin-mediated adhesion and aggregation. However, to prevent thrombotic complications, platelet aggregate formation must be a self-limiting process. The second-wave mediator adenosine diphosphate (ADP) activates platelets via Gq-coupled P2Y

objectiveThe objective of this study was to examine the role of rapid P2Y

methodsWe analyzed a novel knock-in mouse strain expressing a P2Y

resultsP2Y

conclusionOur studies demonstrate that receptor phosphorylation at the C-terminus is critical for P2Y

Indexed as

ThrombosisVascular System InjuriesAdenosine DiphosphateAnimalsBlood PlateletsHemostasisIntegrinsMicePlatelet AggregationReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12Adenosine DiphosphateIntegrinsReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12hemostasisP2Y1 receptorplateletssignalingthrombosis

Identifiers

PMID36958516
PMCPMC10809801
OpenAlexW4328103245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.