Evidence map›Paper›PMID 36958376›Full record

ArticleJournal of medicinal chemistry2023

Serine-/Cysteine-Based sp

Manuel González-Cuesta, Alan Chuan-Ying Lai, Po-Yu Chi, I-Ling Hsu, Nien-Tzu Liu, Ko-Chien Wu, José M García Fernández, Ya-Jen Chang, Carmen Ortiz Mellet

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Manuel González-CuestaDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, Seville E-41012, Spain.ORCID 0000-0003-2778-9489
Alan Chuan-Ying LaiInstitute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan.
Po-Yu ChiInstitute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan.
I-Ling HsuInstitute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan.
Nien-Tzu LiuInstitute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan.
Ko-Chien WuInstitute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan.
José M García FernándezInstituto de Investigaciones Químicas (IIQ), CSIC, Universidad de Sevilla, Américo Vespucio 49, Sevilla E-41092, Spain.ORCID 0000-0002-6827-0387
Ya-Jen ChangInstitute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan.
Carmen Ortiz MelletDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, Seville E-41012, Spain.ORCID 0000-0002-7676-7721
Institute of Biomedical Sciences, Academia Sinica · TWUniversidad de Sevilla · ESCentro de Investigaciones Científicas Isla de la Cartuja · ESChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating the development of proinflammatory responses. Translating them to the clinical setting is hampered by synthetic difficulties, the lack of stability in biological media, and/or a suboptimal profile of balanced immune mediator secretion. Here, we show that replacement of the sugar fragment by an sp

Indexed as

AsthmaToll-Like Receptor 4Adjuvants, ImmunologicAdjuvants, PharmaceuticAnimalsCD8-Positive T-LymphocytesCysteineCytokinesDisease Models, AnimalImmunotherapyMiceMice, Inbred BALB COvalbuminSerineTh2 CellsAdjuvants, ImmunologicAdjuvants, PharmaceuticCysteineCytokinesOvalbuminSerineTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID36958376
PMCPMC10108363
OpenAlexW4360603002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.