Evidence map›Paper›PMID 36958107›Full record

ArticleEpilepsy research2023

Four-Way Wada: SEEG-based mapping with electrical stimulation, high frequency activity, and phase amplitude coupling to complement traditional Wada and functional MRI prior to epilepsy surgery.

D J Bearden, A Ehrenberg, R Selawski, K E Ono, D L Drane, N P Pedersen, I Cernokova, D J Marcus, C Luongo-Zink, J J Chern and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

D J BeardenChildren's Healthcare of Atlanta, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
A EhrenbergNihon Kohden, Irvine, CA, USA.
R SelawskiChildren's Healthcare of Atlanta, Atlanta, GA, USA.
K E OnoChildren's Healthcare of Atlanta, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
D L DraneDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
N P PedersenDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
I CernokovaUniversity of North Texas, TX, USA.
D J MarcusChildren's Healthcare of Atlanta, Atlanta, GA, USA.
C Luongo-ZinkChildren's Healthcare of Atlanta, Atlanta, GA, USA; William James College, Newton, MA, USA.
J J ChernDepartment of Neurosurgery, Children's Healthcare of Atlanta, USA.
C B OliverChildren's Healthcare of Atlanta, Atlanta, GA, USA.
J GanoteChildren's Healthcare of Atlanta, Atlanta, GA, USA.
R Al-RamadhaniUniversity of Pittsburgh Medical Center Children's Hospital, Pittsburgh, PA 15224, USA.
S BhallaChildren's Healthcare of Atlanta, Atlanta, GA, USA.
S GedelaChildren's Healthcare of Atlanta, Atlanta, GA, USA.
G ZhangChildren's Healthcare of Atlanta, Atlanta, GA, USA.
A KhederChildren's Healthcare of Atlanta, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: akheder@emory.edu.

Funding

National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe StructuresR01NS088748 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2014 to 2024
$6.4M
Control of the Hippocampal Formation by the Supramammillary Hypothalamus - Anatomy, Physiology and in a Model of Medial Temporal Lobe EpilepsyK08NS105929 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PEDERSEN, NIGEL PAUL · 2018 to 2023
$963k
Sleep-Wake and Epilepsy Interactions in a Mouse Model of Temporal Lobe EpilepsR21NS122011 · NINDS · EMORY UNIVERSITY · PI PEDERSEN, NIGEL PAUL · 2021 to 2021
$430k
NIMH NIH HHS R01 MH118514NINDS NIH HHS K08 NS105929NINDS NIH HHS R01 NS088748NINDS NIH HHS R21 NS122011
6 · The paper itself

Abstract

Presurgical evaluation of refractory epilepsy involves functional investigations to minimize postoperative deficit. Assessing language and memory is conventionally undertaken using Wada and fMRI, and occasionally supplemented by data from invasive intracranial electroencephalography, such as electrical stimulation, corticortical evoked potentials, mapping of high frequency activity and phase amplitude coupling. We describe the comparative and complementary role of these methods to inform surgical decision-making and functional prognostication. We used Wada paradigm to standardize testing across all modalities. Postoperative neuropsychological testing confirmed deficit predicted based on these methods.

Indexed as

Drug Resistant EpilepsyEpilepsyElectric StimulationElectrocorticographyElectroencephalographyHumansMagnetic Resonance ImagingElectrical stimulation mappingEpilepsy surgeryHigh frequency activityPhase amplitude couplingStereoelectroencephalographyTemporal lobe epilepsy

Identifiers

PMID36958107
PMCPMC11008564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.