ArticleNeurobiology of aging2023
The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.
Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role forbioRxiv : the preprint server for biology · 2026Article
- Old mice fail to integrate a memory update into an existing hippocampal engram.bioRxiv : the preprint server for biology · 2026Article
- Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation.Molecular psychiatry · 2026Article
- Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression.Biology of sex differences · 2025Article
- Multifaceted dynamics of circadian timing system influence aging and longevity.Biogerontology · 2025Review
- Age-related changes in diurnal expression of inflammatory mediators in the brain and peripheral blood of male and female mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Article
- The interval between conditional stimulus onset and unconditional stimulus onset, not training-to-test interval, determines patterns of immediate early gene expression in the anterior retrosplenial cortex.Neurobiology of learning and memory · 2025Article
- Effects of Age and MPTP-Induced Parkinson's Disease on the Expression of Genes Associated with the Regulation of the Sleep-Wake Cycle in Mice.International journal of molecular sciences · 2024Article
- Fear extinction is impaired in aged rats.GeroScience · 2024Article
- Pharmacological HDAC3 inhibition alters memory updating in young and old male mice.Frontiers in molecular neuroscience · 2024Article
- Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation.Journal of biological rhythms · 2023Article
- The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
Aging impairs both circadian rhythms and memory, though the relationship between these impairments is not fully understood. Circadian rhythms are largely dictated by clock genes within the body's central pacemaker, the suprachiasmatic nucleus (SCN), though these genes are also expressed in local clocks throughout the body. As circadian rhythms can directly affect memory performance, one possibility is that memory deficits observed with age are downstream of global circadian rhythm disruptions stemming from the SCN. Here, we demonstrate that expression of clock gene Period1 within a memory-relevant cortical structure, the retrosplenial cortex (RSC), is necessary for incidental learning, and that age-related disruption of Period1 within the RSC-but not necessarily the SCN-contributes to cognitive decline. These data expand the known functions of clock genes beyond maintaining circadian rhythms and suggests that age-associated changes in clock gene expression modulates circadian rhythms and memory performance in a brain region-dependent manner.
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