ArticlePLoS computational biology2023
Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.
Article in PLoS computational biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Substantia nigra pars reticulata involvement in auditory hallucinations of treatment-resistant schizophrenia: a deep brain stimulation case report.Schizophrenia (Heidelberg, Germany) · 2026Article
- Personalized audiovisual gamma stimulation enhances neural connectivity and entrainment beyond fixed 40 Hz protocols.Frontiers in neuroscience · 2026Article
- Transcranial near infrared therapy reprograms metabolism to rescue sleep and place cell functionality.iScience · 2025Article
- Cell-type-specific contributions to theta-gamma coupled rhythms in the hippocampus.Network neuroscience (Cambridge, Mass.) · 2025Article
- Hippocampal and cortical activities reflect early hyperexcitability in an Alzheimer's mouse model.Brain communications · 2025Article
- Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.iScience · 2024Article
- How to design optimal brain stimulation to modulate phase-amplitude coupling?Journal of neural engineering · 2024Article
- Article
- Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.PLoS computational biology · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
Phase amplitude coupling (PAC) between slow and fast oscillations is found throughout the brain and plays important functional roles. Its neural origin remains unclear. Experimental findings are often puzzling and sometimes contradictory. Most computational models rely on pairs of pacemaker neurons or neural populations tuned at different frequencies to produce PAC. Here, using a data-driven model of a hippocampal microcircuit, we demonstrate that PAC can naturally emerge from a single feedback mechanism involving an inhibitory and excitatory neuron population, which interplay to generate theta frequency periodic bursts of higher frequency gamma. The model suggests the conditions under which a CA1 microcircuit can operate to elicit theta-gamma PAC, and highlights the modulatory role of OLM and PVBC cells, recurrent connectivity, and short term synaptic plasticity. Surprisingly, the results suggest the experimentally testable prediction that the generation of the slow population oscillation requires the fast one and cannot occur without it.
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