Evidence map›Paper›PMID 36952350›Full record

Observational studyEndocrinology, diabetes & metabolism2023

Effect of circulating ceramides on adiposity and insulin resistance in patients with type 2 diabetes: An observational cross-sectional study.

Emmanuel K Ofori, Alfred Buabeng, Seth D Amanquah, Kwabena O Danquah, Seth K Amponsah, Wormenor Dziedzorm, Francis K Dogodzi, Laurinda X Adusu-Donkor, Segla K Bernard, Henry Asare-Anane

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Endocrinology, diabetes & metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Observational
  9. Review
  10. Article
  11. Circulating Sphingolipids and Glucose Homeostasis: An Update.International journal of molecular sciences · 2023
    Review
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Emmanuel K OforiDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.ORCID 0000-0001-7375-8830
Alfred BuabengDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.
Seth D AmanquahDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.
Kwabena O DanquahDepartment of Clinical Pathology, NMIMR, University of Ghana, Accra, Ghana.
Seth K AmponsahDepartment of Medical Pharmacology, U.G.M.S, University of Ghana, Accra, Ghana.
Wormenor DziedzormDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.
Francis K DogodziDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.
Laurinda X Adusu-DonkorDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.
Segla K BernardDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.
Henry Asare-AnaneDepartment of Chemical Pathology, U.G.M.S, University of Ghana, Accra, Ghana.
University of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInsulin resistance (IR) is one of the common chronic metabolic disorders in Africa and elsewhere. Accumulation of lipids in the body may be due to an imbalance in the metabolism of lipids, glucose and proteins. Ceramides are a sphingolipid class of lipids that are biologically active and vital in the production of more complex lipids. Circulating ceramides are thought to have a role in the development of obesity-related IR, although the precise involvement remains unclear.

aimTo investigate the impact of circulating ceramide on IR and body adiposity in people with and without type 2 diabetes mellitus (T2DM). METHODOLOGY: The study was observational and cross-sectional. There were a total of 84 volunteers with T2DM and 75 nondiabetics (control). The participants' ages, body mass indexes (BMI), waist circumferences, and blood pressure (BP) were among the clinical parameters assessed. Ceramide levels, fasting plasma glucose (FPG), lipids, basal insulin levels and glycated haemoglobin (HbA1c) were also measured. Additionally, the homeostatic model assessment for IR (HOMA-IR) and beta cell function (HOMA-β) were computed.

resultsT2DM and control participants had different mean values for anthropometric parameters, BP, FPG, HbA1c, lipids, insulin, HOMA-IR, HOMA-β and ceramide levels (p < .05 for all). HOMA-IR, HOMA-β and cardiovascular risk were significant correlates with ceramide levels in the T2DM group (r = 0.24; -0.34; 0.24, p < .05, respectively). Further, FPG (OR = 1.83, p = .01) and ceramide (OR = 1.05, p = .01) levels were significant predictors of IR in the case group.

conclusionPatients with T2DM exhibited high ceramide concentrations, which, when combined with high FPG, were associated with IR. The consequences of circulating ceramides in health and disease; however, merit further research.

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceAdiposityCeramidesCross-Sectional StudiesGlycated HemoglobinHumansInsulinObesityCeramidesGlycated HemoglobinInsulinadiposityceramideinsulin resistance

Identifiers

PMID36952350
PMCPMC10164428
OpenAlexW4360599697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.