ArticleMolecular biology and evolution2023
Stop or Not: Genome-Wide Profiling of Reassigned Stop Codons in Ciliates.
Article in Molecular biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates.Science China. Life sciences · 2025Article
- Predicting the Structural Effects of CUG Codon Translation on Uncharacterized Proteins inJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- The cell biology and genome ofMolecular biology of the cell · 2025Article
- Multiple independent genetic code reassignments of the UAG stop codon in phyllopharyngean ciliates.PLoS genetics · 2024Article
- The P10K database: a data portal for the protist 10 000 genomes project.Nucleic acids research · 2024Article
- Decay of Skin-Specific Gene Modules in Pangolins.Journal of molecular evolution · 2023Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
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Abstract
Bifunctional stop codons that have both translation and termination functions in the same species are important for understanding the evolution and function of genetic codes in living organisms. Considering the high frequency of bifunctional codons but limited number of available genomes in ciliates, we de novo sequenced seven representative ciliate genomes to explore the evolutionary history of stop codons. We further propose a stop codon reassignment quantification method (stopCR) that can identify bifunctional codons and measure their frequencies in various eukaryotic organisms. Using our newly developed method, we found two previously undescribed genetic codes, illustrating the prevalence of bifunctional stop codons in ciliates. Overall, evolutionary genomic analyses suggest that gain or loss of reassigned stop codons in ciliates is shaped by their living environment, the eukaryotic release factor 1, and suppressor tRNAs. This study provides novel clues about the functional diversity and evolutionary history of stop codons in eukaryotic organisms.
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