Evidence map›Paper›PMID 36952010›Full record

ArticleJournal of neurology2023

Assessment of cognitive performance in multiple sclerosis using smartphone-based training games: a feasibility study.

Silvan Pless, Tim Woelfle, Yvonne Naegelin, Johannes Lorscheider, Andrea Wiencierz, Óscar Reyes, Pasquale Calabrese, Ludwig Kappos

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04413032 (DreaMS - Development of Digital Biomarkers in Multiple Sclerosis - Feasibility Study), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04413032 nacompletednot on this map

DreaMS - Development of Digital Biomarkers in Multiple Sclerosis - Feasibility Study

TypeinterventionalSponsorResearch Center for Clinical Neuroimmunology and Neuroscience BaselRan2020 to 2021Enrolled62ConditionsMultiple SclerosisArmsDreaMS
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Plateau of practice effects and noise with repeat SDMT testing in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025
    Article
  5. Article
  6. Observational
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silvan PlessResearch Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0002-9660-9077
Tim WoelfleResearch Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0001-6279-4158
Yvonne NaegelinResearch Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1315-4100
Johannes LorscheiderResearch Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0003-1100-2506
Andrea WiencierzClinical Trial Unit, University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0001-8786-7915
Óscar ReyesHealios AG, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0169-297X
Pasquale CalabreseNeuropsychology and Behavioral Neurology Unit, Department of Psychology and Interdisciplinary Platform Psychiatry and Psychology, Division of Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-3347-5187
Ludwig KapposResearch Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4031, Basel, Switzerland. Ludwig.kappos@usb.ch.ORCID http://orcid.org/0000-0003-4175-5509

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive impairment occurs in up to 70% of people with MS (pwMS) and has a large impact on quality of life and working capacity. As part of the development of a smartphone-app (dreaMS) for monitoring MS disease activity and progression, we assessed the feasibility and acceptance of using cognitive games as assessment tools for cognitive domains.

methodsWe integrated ten cognitive games in the dreaMS app. Participants were asked to play these games twice a week for 5 weeks. All subjects underwent a battery of established neuropsychological tests. User feedback on acceptance was obtained via a five-point Likert-scale questionnaire. We correlated game performance measures with predetermined reference tests (Spearman's rho) and analyzed differences between pwMS and Healthy Controls (rank biserial correlation).

resultsWe included 31 pwMS (mean age 43.4 ± 12.0 years; 68% females; median Expanded Disability Status Scale score 3.0, range 1.0-6.0) and 31 age- and sex-matched HC. All but one game showed moderate-strong correlations with their reference tests, (|r

conclusionModerate-strong correlations with reference tests suggest that adaptive cognitive games may be used as measures of cognitive domains. The practice effects observed suggest that game-derived measures may capture change over time. All games were perceived as enjoyable and meaningful, features crucial for long-term adherence. Our results encourage further validation of adaptive cognitive games as monitoring tools for cognition in larger studies of longer duration. STUDY REGISTER: ClinicalTrials.gov: NCT04413032.

Indexed as

Multiple SclerosisAdultCognitionFeasibility StudiesFemaleHumansMaleMiddle AgedQuality of LifeSmartphoneCognitive assessmentGamificationMonitoring-toolMultiple sclerosisSmartphone-games

Identifiers

PMID36952010
PMCPMC10267276

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.