ArticleInvestigative ophthalmology & visual science2023
A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control.
Article in Investigative ophthalmology & visual science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Influence of outdoor time on the spherical equivalent and axial length in childhood myopia: A meta-analysis.Acta ophthalmologica · 2025Pooled it
- Efficacy of Repeated Low-Level Red Light (RLRL) therapy on myopia outcomes in children: a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Analysis of real-world eye level light exposure through spectacle lens.Npj biological timing and sleep · 2026Article
- Review
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Intensive outdoor activity for 1 week increases choroidal thickness in Japanese schoolchildren: a prospective observational study.BMC ophthalmology · 2025Observational
- Contributions from light level and spectral content on refractive development in young rabbits.International journal of ophthalmology · 2025Article
- Interactions Between High-Intensity Light and Unrestricted Vision in the Drive for Hyperopia.Investigative ophthalmology & visual science · 2024Article
- A Child-Friendly Wearable Device for Quantifying Environmental Risk Factors for Myopia.Translational vision science & technology · 2024Article
- Survey on pattern of myopia in school children in Hangzhou after the COVID-19 pandemic: a school-based vision screening study.BMC public health · 2024Article
- The influence of the environment and lifestyle on myopia.Journal of physiological anthropology · 2024Review
- Nonlinear pathological trajectory of a high-myopia C57/BL6J mouse model induced by form deprivation.Frontiers in physiology · 2024Article
- Objective Measures of Gaze Behaviors and the Visual Environment during Near-Work Tasks in Young Adult Myopes and Emmetropes.Translational vision science & technology · 2023Article
- Spontaneously Myopic Guinea Pig: Model of Early Pathologic Myopia.Investigative ophthalmology & visual science · 2023Article
- Using Light Meters to Investigate the Light-Myopia Association - A Literature Review of Devices and Research Methods.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and unrestricted vision (UnV) on lens-induced myopia (LIM) development in chickens. Methods: Myopia was induced in one eye in chicks (10 groups, n = 126) from day 1 posthatching (D1) until day 8 (D8) using -10 diopter (D) lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to 2, 4, or 6 hours of HL (15,000 lux), UnV (removal of -10 D lens), or both (HL + UnV). One group served as the LIM group without any interventions. Ocular axial length (AL), refractive error, and choroidal thickness were measured on D1, D4, and D8. Outcome measures are expressed as interocular difference (IOD = experimental eye - control eye) ± SEM. Results: By D8, LIM increased AL (0.36 ± 0.04 mm), myopic refraction (-9.02 ± 0.37 D), and choroidal thinning (-90.27 ± 16.44 µm) in the LIM group (all, P < 0.001). Compared to the LIM group, exposure to 2, 4, or 6 hours of HL, UnV, or HL + UnV reduced myopic refraction in a duration-dependent manner, with UnV being more effective than HL (P < 0.05). Only 6 hours of HL + UnV (not 2 or 4 hours) prevented LIM and was more effective than UnV (P = 0.004) or HL (P < 0.001) in reducing myopic refraction and more effective than HL (P < 0.001) in reducing axial elongation. Conclusions: Daily exposure to 2, 4, or 6 hours of HL, UnV, or HL + UnV reduced lens-induced myopic refraction in a duration-dependent manner in chickens. Only 6 hours of HL + UnV completely stopped LIM development. The synergetic effect of HL and UnV is dependent on the duration of the interventions.
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Registered trials
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