Evidence map›Paper›PMID 36951588›Full record

ArticleJournal of bacteriology2023

Amelia Staats, Peter W Burback, Nadia N Casillas-Ituarte, Daniel Li, Michaela R Hostetler, Anne Sullivan, Alexander R Horswill, Steven K Lower, Paul Stoodley

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Altering the interfacial rheology ofFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Amelia Staats *Department of Microbiology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-7563-1403
Peter W Burback *Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-9093-7216
Nadia N Casillas-ItuarteSchool of Earth Sciences, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-7017-9478
Daniel LiDepartment of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0001-7138-4898
Michaela R HostetlerSchool of Earth Sciences, The Ohio State University, Columbus, Ohio, USA.
Anne SullivanDepartment of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0001-9527-3607
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-5568-0096
Steven K LowerDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Paul StoodleyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-6069-273X
The Ohio State University · USThe Ohio State University Wexner Medical Center · USUniversity of Colorado Denver · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
Molecular binding reaction that initiates Staphylococcus aureus infections of carR01HL119648 · NHLBI · OHIO STATE UNIVERSITY · PI LOWER, STEVEN K · 2014 to 2018
$3.0M
The role of Staphylococcus aureus aggregate formation in establishing biofilms in chronic orthopaedic periprosthetic joint infection.R01GM124436 · NIGMS · OHIO STATE UNIVERSITY · PI STOODLEY, PAUL · 2018 to 2021
$2.1M
Structured Illumination Microscope for high resolution imaging of cells and tissuesS10OD025008 · OD · OHIO STATE UNIVERSITY · PI STOODLEY, PAUL · 2019 to 2019
$593k
NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL119648NIAID NIH HHS P01 AI083211NIGMS NIH HHS R01 GM124436NIH HHS S10 OD025008
6 · The paper itself

Abstract

Considerable progress has been made toward elucidating the mechanism of Staphylococcus aureus aggregation in synovial fluid. In this study, aggregate morphology was assessed following incubation under several simulated postsurgical joint conditions. Using fluorescently labeled synovial fluid polymers, we show that aggregation occurs through two distinct mechanisms: (i) direct bridging between S. aureus cells and host fibrinogen and (ii) an entropy-driven depletion mechanism facilitated by hyaluronic acid and albumin. By screening surface adhesin-deficient mutants (

Indexed as

Staphylococcal InfectionsStaphylococcus aureusAdhesins, BacterialAnti-Bacterial AgentsBiofilmsFibrinogenHumansAdhesins, BacterialAnti-Bacterial AgentsFibrinogenaggregationbacterial pathogenesisbiofilmsinfectionorthopedic infectionStaphylococcus aureussynovial fluid

Identifiers

PMID36951588
PMCPMC10127631
OpenAlexW4360599827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.