Evidence map›Paper›PMID 36951578›Full record

ArticleApplied and environmental microbiology2023

A Multi-Enzyme Cascade for Efficient Production of Pyrrolidone from l-Glutamate.

Xuling Jiang, Wanqing Wei, Yaozhong Cui, Wei Song, Yingying Li, Xiulai Chen, Cong Gao, Jia Liu, Liang Guo, Liming Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuling JiangSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.
Wanqing WeiState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Yaozhong CuiJiangsu Xishan Senior High School, Wuxi, China.
Wei SongSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.
Yingying LiState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Xiulai ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.ORCID 0000-0002-9749-4558
Cong GaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.ORCID 0000-0001-8505-2026
Jia LiuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Liang GuoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Liming LiuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Jing WuSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.ORCID 0000-0001-6911-2041

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrrolidone is a high value-added monomer and an important active drug intermediate. However, the efficient enzymatic synthesis of pyrrolidone remains a challenge. Here, we developed and reconstructed a three-enzyme cascade pathway using Escherichia coli BL21(DE3) for the production of pyrrolidone from l-glutamate (l-Glu). The carnitine-CoA ligase from Escherichia coli (

Indexed as

Glutamic AcidMetabolic EngineeringCarnitineEscherichia coliLigasesCarnitineGlutamic AcidLigasesbiocatalysiscarnitine CoA ligaseprotein engineeringpyrrolidone

Identifiers

PMID36951578
PMCPMC10132116

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.