Evidence map›Paper›PMID 36951065›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Endothelial K

Jing-Jing Li, Xin-Yi Zhao, Yan Wang, Rui Xu, Xiao-Hui Di, Yu Zhang, Hongyan Yang, Meng-Zhuan Han, Ru-Yue Bai, Lin Xie and 7 more

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In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Endotheliopathy: Additional Players Slow the Downward Spiral.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Jing-Jing Li *The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, China (J.-J.L., R.X., X.-H.D., L.X., J.Z., W.X.).
Xin-Yi Zhao *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).
Yan Wang *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).
Rui XuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, China (J.-J.L., R.X., X.-H.D., L.X., J.Z., W.X.).
Xiao-Hui DiThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, China (J.-J.L., R.X., X.-H.D., L.X., J.Z., W.X.).
Yu ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).
Hongyan YangDepartment of Aerospace Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China (H.Y., X.Z.).
Meng-Zhuan HanDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).
Ru-Yue BaiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).ORCID 0000-0002-0252-2334
Lin XieThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, China (J.-J.L., R.X., X.-H.D., L.X., J.Z., W.X.).
Zheng-Da PangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).
Xing ZhangDepartment of Aerospace Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China (H.Y., X.Z.).
Jianbao ZhangThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, China (J.-J.L., R.X., X.-H.D., L.X., J.Z., W.X.).
Xiao-Jun DuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).
Xiu-Ling DengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).ORCID 0000-0003-3908-6086
Yi ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.W., Y.Z., M.-Z.H., R.-Y.B., Z.-D.P., X.-J.D., X.-L.D., Y.Z.).
Wenjun XieThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, China (J.-J.L., R.X., X.-H.D., L.X., J.Z., W.X.).ORCID 0000-0003-0493-062X
Zunyi Medical University · CNXi'an Jiaotong University · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundS1P (sphingosine-1-phosphate) has been reported to possess vasodilatory properties, but the underlying pathways are largely unknown.

methodsIsolated mouse mesenteric artery and endothelial cell models were used to determine S1P-induced vasodilation, intracellular calcium, membrane potentials, and calcium-activated potassium channels (K

resultsMesenteric arteries subjected to acute S1P stimulation displayed a dose-dependent vasodilation response, which was attenuated by blocking endothelial K

conclusionsThis study provides evidence for the mechanistic role of K

Indexed as

HypertensionVasodilationAnimalsBlood PressureEndotheliumHomeostasisHumansHuman Umbilical Vein Endothelial CellsIntermediate-Conductance Calcium-Activated Potassium ChannelsLysophospholipidsMiceSmall-Conductance Calcium-Activated Potassium ChannelsSphingosineIntermediate-Conductance Calcium-Activated Potassium ChannelsLysophospholipidsSmall-Conductance Calcium-Activated Potassium ChannelsSphingosinesphingosine 1-phosphateblood pressurecalcium-activated potassium channelsendothelial cellshypertensionsphingosine-1-phosphate

Identifiers

PMID36951065
OpenAlexW4360600082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.