ArticleExperimental physiology2024
The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.
Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Cellular and molecular mechanisms of muscle spindle development and function.Physiology (Bethesda, Md.) · 2026Review
- Piezo2-Initiated Ultrafast Signaling and Its Acquired Channelopathy in Light of Quantum Gravity Theory.International journal of molecular sciences · 2026Review
- Proprioception and Sensorimotor Regulation Across the Day-Night Cycle in Developmental Dyslexia: Toward an Embodied Perspective.Brain sciences · 2026Review
- Identification, characterization, and structure-activity relationship of the ASIC3-selective peptide WRPRFa.Communications chemistry · 2025Article
- Characterisation of spinal ligaments in the embryonic chick.Journal of anatomy · 2025Article
- Calcium regulation of muscle spindle mechanosensory afferent function.Experimental physiology · 2025Article
- A substantial proportion of subjects with adolescent idiopathic scoliosis display spinal and peripheral proprioceptive deficits.Bone & joint open · 2025Article
- The impact of Asic2 deletion on metabolic homeostasis in mice.Physiological reports · 2025Article
- Diversity of Effects of Mechanical Influences on Living Systems and Aqueous Solutions.International journal of molecular sciences · 2025Review
- Ocular and General Proprioception in Dyslexic Children: A Review of Their Diurnal and Nocturnal Dysfunctions and Their Repercussions.Vision (Basel, Switzerland) · 2025Review
- Differential encoding of mammalian proprioception by voltage-gated sodium channels.Science advances · 2025Article
- Proton-Mediated PIEZO2 Channelopathy: Linking Oxaliplatin Treatment to Impaired Proprioception and Cognitive Deficits.Cancers · 2024Article
- Article
- Genetic exploration of roles of acid-sensing ion channel subtypes in neurosensory mechanotransduction including proprioception.Experimental physiology · 2024Review
- Commentary: Effects of combined treatment with transcranial and peripheral electromagnetic stimulation on performance and pain recovery from delayed onset muscle soreness induced by eccentric exercise in young athletes. A randomized clinical trial.Frontiers in physiology · 2024Article
- The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.Experimental physiology · 2024Article
- Experimental Physiology special issue: 'Mechanotransduction, muscle spindles and proprioception'.Experimental physiology · 2024Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
By translating mechanical forces into molecular signals, proprioceptive neurons provide the CNS with information on muscle length and tension, which is necessary to control posture and movement. However, the identities of the molecular players that mediate proprioceptive sensing are largely unknown. Here, we confirm the expression of the mechanosensitive ion channel ASIC2 in proprioceptive sensory neurons. By combining in vivo proprioception-related functional tests with ex vivo electrophysiological analyses of muscle spindles, we showed that mice lacking Asic2 display impairments in muscle spindle responses to stretch and motor coordination tasks. Finally, analysis of skeletons of Asic2 loss-of-function mice revealed a specific effect on spinal alignment. Overall, we identify ASIC2 as a key component in proprioceptive sensing and a regulator of spine alignment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.