Evidence map›Paper›PMID 36950893›Full record

ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023

Implantation of contemporary transcatheter aortic valves in small aortic annuli: the international multicentre TAVI-SMALL 2 registry.

Pier Pasquale Leone, Damiano Regazzoli, Matteo Pagnesi, Francesco Cannata, Antonio Mangieri, Thijmen W Hokken, Giuliano Costa, Marco Barbanti, Rui Campante Teles, Marianna Adamo and 25 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Relationship between a small aortic annulus and clinical and quality-of-life outcomes in patients undergoing TAVR.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Transcatheter aortic valve implantation: latest evidence, gaps in knowledge, and future directions.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025
    Review
  11. Article
  12. Article
  13. DurAVR - a novel biomimetic balloon-expandable transcatheter valve for TAVI, valve-in-valve TAVI and redo-TAVI.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Article
  14. Article
  15. TAVI vs SAVR: The timeless showdown in aortic valve replacement.International journal of cardiology. Heart & vasculature · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 14 institutions in 5 countries.

Pier Pasquale LeoneMontefiore Medical Center, New York, NY, USA.
Damiano RegazzoliCardio Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
Matteo PagnesiInstitute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Francesco CannataDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.
Antonio MangieriCardio Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
Thijmen W HokkenDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands.
Giuliano CostaU.O.C. Cardiologia, Centro Alte Specialità e Trapianti, A.O.U. Policlinico "G. Rodolico-San Marco", Catania, Italy.
Marco BarbantiU.O.C. Cardiologia, Centro Alte Specialità e Trapianti, A.O.U. Policlinico "G. Rodolico-San Marco", Catania, Italy.
Rui Campante TelesHospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Nova Medical School, CEDOC, Lisbon, Portugal.
Marianna AdamoInstitute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Maurizio TaramassoHerzZentrum Hirslanden Zurich, Zurich, Switzerland and University of Zurich, Zurich, Switzerland.
Jorg ReifartDZHK (German Center for Cardiovascular Research), Partner Site RheinMain, Frankfurt am Main, Germany.
Federico De MarcoDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Francesco GianniniGVM Care & Research, Maria Cecilia Hospital, Ravenna, Italy.
Faraj KargoliMontefiore Medical Center, New York, NY, USA.
Yohei OhnoDepartment of Cardiology, Tokai University Hospital, Kanagawa, Japan.
Francesco SaiaCardiology Unit, Sant'Orsola Polyclinic, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Andrea BuonoInterventional Cardiology Unit, Cardiovascular Department, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Alfonso IelasiClinical and Interventional Unit, Sant'Ambrogio Cardio-Thoracic Center, Milan, Italy.
Michele PighiDivision of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Mauro ChiaritoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.
Dario BongiovanniCardio Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
Ottavia CozziCardio Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
Giulio StefaniniDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.
Flavio L RibichiniDivision of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Diego MaffeoInterventional Cardiology Unit, Cardiovascular Department, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Giuliano ChizzolaInstitute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Francesco BedogniGVM Care & Research, Maria Cecilia Hospital, Ravenna, Italy.
Won-Keun KimDepartment of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany.
Francesco MaisanoCardio-Thoracic-Vascular Department, IRCCS Ospedale San Raffaele, Milan, Italy.Misc.
Corrado TamburinoHospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Nova Medical School, CEDOC, Lisbon, Portugal.
Nicolas M Van MieghemDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands.
Antonio ColomboDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.
Bernhard ReimersCardio Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
Azeem LatibMontefiore Medical Center, New York, NY, USA.
Humanitas University · ITIRCCS Humanitas Research Hospital · ITUniversity of Brescia · ITFondazione Poliambulanza Istituto Ospedaliero · ITHospital de Santa Cruz · PTMaria Cecilia Hospital · ITMontefiore Medical Center · USPoliclinico Universitario di Catania · ITUniversity of Verona · ITGerman Centre for Cardiovascular Research · DEIRCCS Policlinico San Donato · ITIstituto Clinico Sant'Ambrogio · ITKerckhoff Klinik · DETokai University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment of aortic stenosis in patients with small annuli is challenging and can result in prosthesis-patient mismatch (PPM).

aimsWe aimed to compare the forward flow haemodynamics and clinical outcomes of contemporary transcatheter valves in patients with small annuli.

methodsThe TAVI-SMALL 2 international retrospective registry included 1,378 patients with severe aortic stenosis and small annuli (annular perimeter <72 mm or area <400 mm

resultsThe predischarge mean aortic gradient was lower after SAV versus IAV (7.8±3.9 vs 12.0±5.1; p<0.001) and SEV versus BEV implantation (8.0±4.1 vs 13.6±4.7; p<0.001). Severe PPM was more common with IAV and BEV when compared to SAV and SEV implantation, respectively, (8.8% vs 3.6%; p=0.007 and 8.7% vs 4.6%; p=0.041). At multivariable logistic regression weighted by IPTW, SAV protected from severe PPM regardless of its definition. More than mild PVL occurred more often with SEV versus BEV (11.6% vs 2.6%; p<0.001).

conclusionsIn small aortic annuli, implantation of SAV and SEV was associated with a more favourable forward haemodynamic profile than after IAV and BEV implantation, respectively. More than mild PVL was more common after SEV than BEV implantation.

Indexed as

Aortic Valve StenosisHeart Valve ProsthesisTranscatheter Aortic Valve ReplacementAortic ValveHumansProsthesis DesignRegistriesRetrospective StudiesTreatment Outcome

Identifiers

PMID36950893
PMCPMC10266383
OpenAlexW4360599732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.