Evidence map›Paper›PMID 36950854›Full record

ArticleRenal failure2023

Intraoperative dexmedetomidine use is associated with lower incidence of acute kidney injury after non-cardiac surgery.

Yong-Zhong Tang, Qiong Wang, Li Zhi, Xing Liu, Yuan Le, Qin Liao, Bo Li, Wei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yong-Zhong TangDepartment of Anesthesiology of the Third Xiangya Hospital, Central South University, Changsha, China.
Qiong WangDepartment of Cardiology of the Third Xiangya Hospital, Central South University, Changsha, China.
Li ZhiDepartment of Nephrology of the Third Xiangya Hospital, Central South University, Changsha, China.
Xing LiuDepartment of Anesthesiology of the Third Xiangya Hospital, Central South University, Changsha, China.
Yuan LeDepartment of Anesthesiology of the Third Xiangya Hospital, Central South University, Changsha, China.
Qin LiaoDepartment of Anesthesiology of the Third Xiangya Hospital, Central South University, Changsha, China.
Bo LiOperation center of the Third Xiangya Hospital, Central South University, Changsha, China.
Wei ZhangDepartment of Nephrology of the Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that perioperative dexmedetomidine could reduce the incidence of postoperative AKI in cardiovascular surgery, however, its effectiveness in the non-cardiovascular surgery patient population has not been reported. The aim of this study was to investigate the effect of intraoperative dexmedetomidine on the incidence of postoperative AKI and postoperative ICU admissions in patients undergoing non-cardiovascular surgery. DESIGN AND

settingA single-center retrospective cohort study obtained from the database of the Center for Anesthesia and Surgery, the Third Xiangya Hospital. PATIENTS: Inpatients between 18 and 75 years of age who were admitted to our hospital for non-cardiovascular surgery from 2012 to 2019.

resultsOverall 2391 patients who used dexmedetomidine intraoperatively were analyzed in comparison to 4552 patients who did not use dexmedetomidine after one-to-two matching. The two cohorts had similar baseline values and demographic characteristics. The incidence of AKI was lower in patients with intraoperative dexmedetomidine use than in the nonuse group (OR 0.60,

conclusionFor non-cardiovascular surgery patient population, intraoperative use of dexmedetomidine was associated with a lower incidence and less severity of postoperative AKI. However, there was no significant correlation with postoperative ICU occupancy or in-hospital mortality. Further prospective RCTs are needed in the future.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresDexmedetomidineHumansIncidenceRetrospective StudiesDexmedetomidineacute kidney injuryDexmedetomidinenon-cardiovascular surgeryretrospective study

Identifiers

PMID36950854
PMCPMC10038018
OpenAlexW4360599768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.