Evidence map›Paper›PMID 36950724›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management.

Li Wang, Guopu Chen, Lu Fan, Hanxu Chen, Yuanjin Zhao, Ling Lu, Luoran Shang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Enzyme-Integrated Hydrogels for Advanced Biological Applications.Polymer science & technology (Washington, D.C.) · 2026
    Review
  5. Article
  6. Nanozymes-Armed ProbioticResearch (Washington, D.C.) · 2026
    Article
  7. Bioinspired Real-Time Dynamic Responsive Structural Colors.Polymer science & technology (Washington, D.C.) · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Glucose Responsive Coacervate Protocells from Microfluidics for Diabetic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li WangDepartment of Otolaryngology Head and Neck Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.ORCID 0000-0001-5543-3725
Guopu ChenDepartment of Otolaryngology Head and Neck Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Lu FanDepartment of Otolaryngology Head and Neck Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Hanxu ChenDepartment of Otolaryngology Head and Neck Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Yuanjin ZhaoDepartment of Otolaryngology Head and Neck Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.ORCID 0000-0001-9242-4000
Ling LuDepartment of Otolaryngology Head and Neck Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Luoran ShangDepartment of Otolaryngology Head and Neck Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2021B1515120054National Key Research and Development Program of China 2020YFA0908200National Natural Science Foundation of China 52073060National Natural Science Foundation of China 61927805Shenzhen Fundamental Research Program JCYJ20190813152616459Shenzhen Fundamental Research Program JCYJ20210324133214038
6 · The paper itself

Abstract

Hard-healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend to achieve multistage promotion and real-time reporting to facilitate wound management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for wound healing, which is intergated with glucose oxidase (GOD) and copper peroxide (CP). Such microparticles are composed of biofriendly hyaluronic acid methacryloyl (HAMA) and pH-responsive acrylic acid (AA), which provided abundant binding sites and spaces for chemical immobilizing and physical doping of enzymes and metal bioinorganics. When the cascade catalytic system is applied on wound sites, hyperglycemia environment would serve as a hydrogen peroxide (H

Indexed as

Diabetes MellitusHydrogelsAnti-Bacterial AgentsBiomimeticsHumansWound HealingAnti-Bacterial AgentsHydrogelsantibacterialhydrogelinverse opalreactive oxygen species (ROS)wound healing

Identifiers

PMID36950724
PMCPMC10190660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.