Evidence map›Paper›PMID 36950615›Full record

ArticleHeliyon2023

Obligate role for Rock1 and Rock2 in adult stem cell viability and function.

Arivazhagan Sambandam, Elaine Storm, Helen Tauc, Jason A Hackney, David Garfield, Patrick Caplazi, John Liu, Juan Zhang, Hua Zhang, Jeff Duggan and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Arivazhagan SambandamDepartment of Immunology Discovery, Genentech Inc., South San Francisco, CA, USA.
Elaine StormDepartment of Molecular Oncology, Genentech Inc., South San Francisco, CA, USA.
Helen TaucDepartment of Immunology Discovery, Genentech Inc., South San Francisco, CA, USA.
Jason A HackneyDepartment of Bioinformatics, Genentech Inc., South San Francisco, CA, USA.
David GarfieldDepartment of Bioinformatics, Genentech Inc., South San Francisco, CA, USA.
Patrick CaplaziDepartment of Research Pathology, Genentech Inc., South San Francisco, CA, USA.
John LiuDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Juan ZhangDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Hua ZhangDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Jeff DugganDepartment of Immunology Discovery, Genentech Inc., South San Francisco, CA, USA.
Surinder JeetDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Sarah GierkeDepartment of Research Pathology, Genentech Inc., South San Francisco, CA, USA.
Patrick ChangDepartment of Research Pathology, Genentech Inc., South San Francisco, CA, USA.
Xiumin WuDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Robert NewmanDepartment of Research Biology, Genentech Inc., South San Francisco, CA, USA.
Lucinda TamDepartment of Research Biology, Genentech Inc., South San Francisco, CA, USA.
Tuija AlcantarDepartment of Research Biology, Genentech Inc., South San Francisco, CA, USA.
Lifen WangDepartment of Cancer Immunology, Genentech Inc., South San Francisco, CA, USA.
Meron Roose-GirmaDepartment of Research Biology, Genentech Inc., South San Francisco, CA, USA.
Zora ModrusanDepartment of Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Wyne P LeeDepartment of Translational Immunology, Genentech Inc., South San Francisco, CA, USA.
Heinrich JasperDepartment of Immunology Discovery, Genentech Inc., South San Francisco, CA, USA.
Frederic de SauvageDepartment of Molecular Oncology, Genentech Inc., South San Francisco, CA, USA.
Rajita PappuDepartment of Immunology Discovery, Genentech Inc., South San Francisco, CA, USA.
Molecular Oncology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter these processes can cause primary immunodeficiencies, malignancies and defects in barrier function. The Rho-kinases, Rock1 and Rock2, regulate cell shape and cytoskeletal rearrangement, activities essential to mitosis. Here, we use inducible gene targeting to ablate

Indexed as

CytokinesisHematopoiesisIntestinal regenerationRho kinasesStem cells

Identifiers

PMID36950615
PMCPMC10025895
OpenAlexW4323654594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.