Evidence map›Paper›PMID 36950495›Full record

ArticleJournal of clinical and experimental hepatology

Herb-induced Liver Injury-A Guide to Approach. Lessons from the

Aabha Nagral, Omkar S Rudra, Sherna Menezes, Sasikumar Menon, Sunita Shailajan, Snehal Mallakmir, Rajender Reddy

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Embracing Progress and Unveiling Innovations.Journal of clinical and experimental hepatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Aabha NagralDepartment of Gastroenterology, Jaslok Hospital & Research Centre, Peddar Road, Mumbai, India.
Omkar S RudraDepartment of Critical Care Medicine, Jaslok Hospital & Research Centre, Peddar Road, Mumbai, India.
Sherna MenezesDepartment of Gastroenterology, Jaslok Hospital & Research Centre, Peddar Road, Mumbai, India.
Sasikumar MenonPharma Analytical Sciences, Ramnarain Ruia Autonomous College, Matunga, Mumbai, India.
Sunita ShailajanDepartment of Botany, Ramnarain Ruia Autonomous College, Matunga, Mumbai, India.
Snehal MallakmirCentre for Genomic Medicine, Apollo Hospital, Navi Mumbai, India.
Rajender ReddyDivision of Hepatology, University of Pennsylvania, 3400, Spruce Street, 2 Dulles, Philadelphia, PA 19104, USA.
Apollo Hospitals · INJaslok Hospital · INUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: We collected the four plant samples and two commercial preparations that were consumed by our patients for further analysis. The six samples underwent high performance thin layer chromatography phytochemical analysis and DNA barcoding studies for the confirmation of the genus and species. The four plant part samples which included stems and leaves were also analysed by a botanist for the characteristic morphological and microscopic features. Results: Based on morphological, microscopic, phytochemical and DNA studies, the four plant part samples were identified as TC. The two commercial preparations could not be analysed on phytochemical analysis or DNA barcoding studies due to other ingredients that most likely interfered with the analysis. The herb consumed by our study subjects was confirmed to be Conclusion: We have highlighted the key morphological and phytochemical differences between these two species. We propose an algorithmic approach to accurately identify the implicated herb in cases of HILI. Future studies on causality need to focus on the serological/histopathological identification of active herb/metabolites in human tissues.

Indexed as

COVID-19, Coronavirus Disease 2019DILI, Drug Induced Liver InjuryDNA, Deoxyribonucleic Aciddrug-induced liver injuryGiloyherb-induced liver injuryHILI, Herb-Induced Liver InjuryHPTLC, High Performance Thin Layer ChromatographyRUCAM, Roussel Uclaf Causality Assessment MethodTCR, Tinospora CrispaTC, Tinospora CordifoliaTinospora cordifoliaTinospora crispa

Identifiers

PMID36950495
PMCPMC10025683
OpenAlexW4308454754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.