Evidence map›Paper›PMID 36950485›Full record

ReviewJournal of clinical and experimental hepatology

A Review of Machine Perfusion Strategies in Liver Transplantation.

Amay Banker, Neha Bhatt, Prashantha S Rao, Pravin Agrawal, Mitul Shah, Madhavi Nayak, Ravi Mohanka

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. [Advances in liver transplantation technology].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  7. Article
  8. Article
  9. The Individual Impact of Machine Perfusion on Liver and Kidney on Donor Expansion in Simultaneous Liver and Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Characteristics of Gram-positive cocci infection and the therapeutic effect after liver transplantation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amay BankerDepartment of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.
Neha BhattDepartment of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.
Prashantha S RaoDepartment of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.
Pravin AgrawalDepartment of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.
Mitul ShahDepartment of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.
Madhavi NayakDepartment of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.
Ravi MohankaDepartment of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.
Sir H.N. Reliance Foundation Hospital and Research Centre · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acceptance of liver transplantation as the standard of care for end-stage liver diseases has led to a critical shortage of donor allografts. To expand the donor organ pool, many countries have liberalized the donor criteria including extended criteria donors and donation after circulatory death. These marginal livers are at a higher risk of injury when they are preserved using the standard static cold storage (SCS) preservation techniques. In recent years, research has focused on optimizing organ preservation techniques to protect these marginal livers. Machine perfusion (MP) of the expanded donor liver has witnessed considerable advancements in the last decade. Research has showed MP strategies to confer significant advantages over the SCS techniques, such as longer preservation times, viability assessment and the potential to recondition high risk allografts prior to implantation. In this review article, we address the topic of MP in liver allograft preservation, with emphasis on current trends in clinical application. We discuss the relevant clinical trials related to the techniques of hypothermic MP, normothermic MP, hypothermic oxygenated MP, and controlled oxygenated rewarming. We also discuss the potential applications of ex vivo therapeutics which may be relevant in the future to further optimize the allograft prior to transplantation.

Indexed as

ALP, Alkaline phosphataseALT, Alanine transaminaseASO, Antisense oligonucleotidesAST, Aspartate transaminaseCIT, Cold ischemia timesCOPE, Consortium for Organ Preservation in EuropeCOR, Controlled oxygenated rewarmingDBD, Donation after brain deathDCD, Donation after circulatory deathDHOPE, dual hypothermic oxygenated machine perfusionEAD, Early allograft dysfunctionECD, Extended criteria donorsETC, Electron transport chainGGT, Gamma glutamyl transferaseHCV, Hepatitis C virusHMP, Hypothermic machine perfusionHOPE, Hypothermic oxygenated machine perfusionhypothermic machine perfusionhypothermic oxygenated machine perfusionICU, Intensive care unitIGL, Institute George Lopez-1INR, International normalized ratioIRI, ischemia reperfusion injuryLDH, Lactate dehydrogenasemachine perfusionMELD, Model for end-stage liver diseaseMP, Machine perfusionNAS, Non-anastomotic biliary stricturesNMP, Normothermic machine perfusionNO, Nitric oxidenormothermic machine perfusionPNF, Primary nonfunctionROS, Reactive oxygen speciesRT-PCR, Reverse transcription polymerase chain reactionSNMP, Sub-normothermic machine perfusionstatic cold storageUW, University of WisconsinWIT, Warm ischemia times

Identifiers

PMID36950485
PMCPMC10025749
OpenAlexW4293744181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.