ArticleCell genomics2023
Extraordinary selection on the human X chromosome associated with archaic admixture.
Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Local ancestry inference identifies robust evidence of selection in Neolithic Europe.Molecular biology and evolution · 2026Article
- Comparing Neanderthal Introgression Maps Reveals Core Agreement But Substantial Heterogeneity.Molecular biology and evolution · 2026Article
- Signatures of sex ratio distortion in humans.bioRxiv : the preprint server for biology · 2026Article
- X-linked competition - implications for human development and disease.Nature reviews. Genetics · 2025Review
- Archaic hominin admixture and its consequences for modern humans.Current opinion in genetics & development · 2025Review
- Multiple-testing corrections in selection scans using identity-by-descent segments.bioRxiv : the preprint server for biology · 2025Article
- Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans.Science (New York, N.Y.) · 2024Article
- Saltational Episodes of Reticulate Evolution in the Drosophila saltans Species Group.Molecular biology and evolution · 2024Article
- Neandertal ancestry through time: Insights from genomes of ancient and present-day humans.bioRxiv : the preprint server for biology · 2024Article
- Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci.NPJ Parkinson's disease · 2024Article
- TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting.PLoS genetics · 2024Article
- Ghost admixture in eastern gorillas.Nature ecology & evolution · 2023Article
- Integrating sex-bias into studies of archaic introgression on chromosome X.PLoS genetics · 2023Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The X chromosome in non-African humans shows less diversity and less Neanderthal introgression than expected from neutral evolution. Analyzing 162 human male X chromosomes worldwide, we identified fourteen chromosomal regions where nearly identical haplotypes spanning several hundred kilobases are found at high frequencies in non-Africans. Genetic drift alone cannot explain the existence of these haplotypes, which must have been associated with strong positive selection in partial selective sweeps. Moreover, the swept haplotypes are entirely devoid of archaic ancestry as opposed to the non-swept haplotypes in the same genomic regions. The ancient Ust'-Ishim male dated at 45,000 before the present (BP) also carries the swept haplotypes, implying that selection on the haplotypes must have occurred between 45,000 and 55,000 years ago. Finally, we find that the chromosomal positions of sweeps overlap previously reported hotspots of selective sweeps in great ape evolution, suggesting a mechanism of selection unique to X chromosomes.
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