Evidence map›Paper›PMID 36950250›Full record

ArticleBioMed research international2022

Diagnostic Values of Laboratory Biomarkers in Predicting a Severe Course of COVID-19 on Hospital Admission.

Anusha Tummala, Venkat Ramesh, Nagalla Balakrishna, Rajeswari Koyyada, Anula Divyash Singh, Sreekanth Patnam, M Satish Kumar, Sneha Varahala, Sasidhar V Manda, Suneetha Narreddy

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Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Anusha TummalaApollo Hospitals Educational and Research Foundation (AHERF), Cell and Molecular Biology Research Lab, 500033, Hyderabad, India.ORCID https://orcid.org/0000-0001-8116-803X
Venkat RameshDepartment of Infectious Diseases, Apollo Health City, Jubilee Hills, Hyderabad 500033, India.
Nagalla BalakrishnaDepartment of Biostatistics, Apollo Institute of Medical Science and Research (AIMSR), Jubilee Hills, Hyderabad 500033, India.
Rajeswari KoyyadaApollo Hospitals Educational and Research Foundation (AHERF), Cell and Molecular Biology Research Lab, 500033, Hyderabad, India.ORCID https://orcid.org/0000-0001-5114-2701
Anula Divyash SinghApollo Hospitals Educational and Research Foundation (AHERF), Cell and Molecular Biology Research Lab, 500033, Hyderabad, India.ORCID https://orcid.org/0000-0001-8206-8719
Sreekanth PatnamApollo Hospitals Educational and Research Foundation (AHERF), Cell and Molecular Biology Research Lab, 500033, Hyderabad, India.ORCID https://orcid.org/0000-0002-5213-1470
M Satish KumarBlood Bank and Transfusion Unit, Apollo Health City, Jubilee Hills, 500033, Hyderabad, India.
Sneha VarahalaDepartment of Infectious Diseases, Apollo Health City, Jubilee Hills, Hyderabad 500033, India.
Sasidhar V MandaApollo Hospitals Educational and Research Foundation (AHERF), Cell and Molecular Biology Research Lab, 500033, Hyderabad, India.ORCID https://orcid.org/0000-0002-5981-5277
Suneetha NarreddyDepartment of Infectious Diseases, Apollo Health City, Jubilee Hills, Hyderabad 500033, India.
Apollo Hospitals · INApollo Hospitals · INApollo Institute of Medical Sciences & Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: We intend to identify differences in the clinicodemographic and laboratory findings of COVID-19 patients to predict disease severity and outcome on admission. Methods: This single-centred retrospective study retrieved laboratory and clinical data from 350 COVID-19 patients on admission, represented as frequency tables. A multivariate regression model was used to assess the statistically significant association between the explanatory variables and COVID-19 infection outcomes, where adjusted odds ratio (AOR), Results: Among the 350 COVID-19 patients studied, there was a significant increase in the WBC count, neutrophils, aggregate index of systemic inflammation (AISI), neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte and platelet ratio (NLPR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), D-dimer, interleukin-6 (IL-6), ferritin, lactate dehydrogenase (LDH), prothrombin time (PT), glucose, urea, urea nitrogen, creatinine, alanine phosphatase (ALP), and aspartate aminotransferase (AST) and a significant decrease in lymphocytes, eosinophils, total protein, albumin, prealbumin serum, and albumin/globulin (A/G) ratio in the severe group when compared with the mild and moderate groups. However, after adjusting their age, gender, and comorbidities, WBC count (adjusted odds ratio (AOR) = 6.888, 95% CI = 1.590-29.839,

Indexed as

COVID-19AlbuminsBiomarkersCOVID-19 TestingHospitalsHumansInflammationNeutrophilsRetrospective StudiesUreaAlbuminsBiomarkersUrea

Identifiers

PMID36950250
PMCPMC10027459
OpenAlexW4308457766

What OpenQuestion holds

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LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.