Evidence map›Paper›PMID 36950228›Full record

ReviewBiomedical optics express2023

Evolution of adaptive optics retinal imaging [Invited].

David R Williams, Stephen A Burns, Donald T Miller, Austin Roorda

Open access · goldAbstract readReview
In one paragraph

Review in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 74 citations in OpenAlex.

  1. AI-driven multimodal retinal imaging for early detection and risk stratification of vascular and neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

David R WilliamsThe Institute of Optics and the Center for Visual Science, University of Rochester, Rochester NY, USA.
Stephen A BurnsSchool of Optometry, Indiana University at Bloomington, Bloomington IN, USA.ORCID https://orcid.org/0000-0001-5348-035X
Donald T MillerSchool of Optometry, Indiana University at Bloomington, Bloomington IN, USA.
Austin RoordaHerbert Wertheim School of Optometry and Vision Science, University of California at Berkeley, Berkeley CA, USA.ORCID https://orcid.org/0000-0002-3785-0848
Indiana University Bloomington · USUniversity of California, Berkeley · USUniversity of Rochester · US

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI Susana Marcos · 1985 to 2026
$17.5M
Advanced Technology to Study Visual Function on a Cellular ScaleR01EY023591 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUNCAN, JACQUE LYNNE, ROORDA, AUSTIN · 2014 to 2023
$11.2M
Optical Imaging of the Photoreceptor-RPE ComplexR01EY018339 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI MILLER, DONALD T · 2007 to 2025
$7.7M
Optoretinography: All-optical measures of functional activity in the human retinaU01EY032055 · NEI · UNIVERSITY OF WASHINGTON · PI PALANKER, DANIEL V, ROORDA, AUSTIN · 2021 to 2025
$5.2M
Adaptive Optics Imaging of Human Retinal Vascular Structure and FunctionR01EY024315 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI BURNS, STEPHEN A · 2015 to 2024
$4.3M
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate EyeR01EY031467 · NEI · UNIVERSITY OF ROCHESTER · PI DAVID R WILLIAMS · 2021 to 2026
$3.5M
Imaging spatial and temporal dynamics of retinal ganglion cellsR01EY029808 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI MILLER, DONALD T · 2019 to 2022
$1.7M
NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY018339NEI NIH HHS R01 EY023591NEI NIH HHS R01 EY024315NEI NIH HHS R01 EY029808NEI NIH HHS R01 EY031467NEI NIH HHS U01 EY032055
6 · The paper itself

Abstract

This review describes the progress that has been achieved since adaptive optics (AO) was incorporated into the ophthalmoscope a quarter of a century ago, transforming our ability to image the retina at a cellular spatial scale inside the living eye. The review starts with a comprehensive tabulation of AO papers in the field and then describes the technological advances that have occurred, notably through combining AO with other imaging modalities including confocal, fluorescence, phase contrast, and optical coherence tomography. These advances have made possible many scientific discoveries from the first maps of the topography of the trichromatic cone mosaic to exquisitely sensitive measures of optical and structural changes in photoreceptors in response to light. The future evolution of this technology is poised to offer an increasing array of tools to measure and monitor in vivo retinal structure and function with improved resolution and control.

Identifiers

PMID36950228
PMCPMC10026580
OpenAlexW4320896631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.