Evidence map›Paper›PMID 36950144›Full record

ArticleFrontiers in toxicology2023

Maternal nano-titanium dioxide inhalation alters fetoplacental outcomes in a sexually dimorphic manner.

Julie A Griffith, Allison Dunn, Evan DeVallance, Kallie J Schafner, Kevin J Engles, Thomas P Batchelor, William T Goldsmith, Kimberley Wix, Salik Hussain, Elizabeth C Bowdridge and 1 more

Open access · goldFull text read
In one paragraph

Article in Frontiers in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024
    Guideline
  2. Review
  3. Article
  4. Article
  5. Article
  6. NNanotoxicology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Julie A GriffithDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Allison DunnDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Evan DeVallanceDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Kallie J SchafnerDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Kevin J EnglesDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Thomas P BatchelorDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
William T GoldsmithDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Kimberley WixDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Salik HussainDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Elizabeth C BowdridgeDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
Timothy R NurkiewiczDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States.
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Remote Microvascular Dysfunction After Particulate Matter ExposureR01ES015022 · NIEHS · WEST VIRGINIA UNIVERSITY · PI NURKIEWICZ, TIMOTHY R · 2007 to 2021
$4.9M
Stroke and Alzheimers Disease Related DementiasT32AG052375 · NIA · WEST VIRGINIA UNIVERSITY · PI Paul D Chantler, BERNARD G. SCHREURS · 2017 to 2026
$3.5M
Inflammatory cross-talk between heat events and air pollutionR01ES031253 · NIEHS · WEST VIRGINIA UNIVERSITY · PI HUSSAIN, SALIK · 2020 to 2024
$3.5M
Pre-doctoral Training in Systems ToxicologyT32ES032920 · NIEHS · WEST VIRGINIA UNIVERSITY · PI Timothy R Nurkiewicz · 2022 to 2026
$1.2M
NIA NIH HHS T32 AG052375NIEHS NIH HHS R01 ES015022NIEHS NIH HHS R01 ES031253NIEHS NIH HHS T32 ES032920NIGMS NIH HHS P20 GM103434NIGMS NIH HHS U54 GM104942NIOSH CDC HHS K01 OH012320
6 · The paper itself

Abstract

The placenta plays a critical role in nutrient-waste exchange between the maternal and fetal circulations, thus functioning as an interface that profoundly impacts fetal growth and development. The placenta has long been considered an asexual organ, but, due to its embryonic origin it shares the same sex as the fetus. Exposures to toxicant such as diesel exhaust, have been shown to result in sexually dimorphic outcomes like decreased placental mass in exposed females. Therefore, we hypothesize that maternal nano-TiO

Indexed as

placental flowprostacyclinsexual dimoprhismthromboxane (TXA2)titanium dioxide

Identifiers

PMID36950144
PMCPMC10025460
OpenAlexW4323316750

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read74
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.