Evidence map›Paper›PMID 36950061›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2023

A Pilot Study Exploring Temporal Development of Gut Microbiome/Metabolome in Breastfed Neonates during the First Week of Life.

Imad Awan, Emily Schultz, John D Sterrett, Lamya'a M Dawud, Lyanna R Kessler, Deborah Schoch, Christopher A Lowry, Lori Feldman-Winter, Sangita Phadtare

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Imad AwanDepartment of Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.ORCID https://orcid.org/0000-0003-1038-2965
Emily SchultzDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA.ORCID https://orcid.org/0009-0006-3695-0691
John D SterrettDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.ORCID https://orcid.org/0000-0002-0931-7181
Lamya'a M DawudDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.ORCID https://orcid.org/0000-0003-1810-4927
Lyanna R KesslerDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.ORCID https://orcid.org/0000-0002-0021-7969
Deborah SchochCooper Medical School of Rowan University and Cooper University Hospital, Camden, NJ, USA.
Christopher A LowryDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.ORCID https://orcid.org/0000-0003-3920-5575
Lori Feldman-WinterCooper Medical School of Rowan University and Cooper University Hospital, Camden, NJ, USA.ORCID https://orcid.org/0000-0002-1049-6068
Sangita PhadtareDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA.ORCID https://orcid.org/0000-0002-4388-6150
University of Colorado Boulder · USCooper Medical School of Rowan University · USCooper University Hospital · USLoma Linda University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Exclusive breastfeeding promotes gut microbial compositions associated with lower rates of metabolic and autoimmune diseases. Its cessation is implicated in increased microbiome-metabolome discordance, suggesting a vulnerability to dietary changes. Formula supplementation is common within our low-income, ethnic-minority community. We studied exclusively breastfed (EBF) neonates' early microbiome-metabolome coupling in efforts to build foundational knowledge needed to target this inequality. Methods: Maternal surveys and stool samples from seven EBF neonates at first transitional stool (0-24 hours), discharge (30-48 hours), and at first appointment (days 3-5) were collected. Survey included demographics, feeding method, medications, medical history and tobacco and alcohol use. Stool samples were processed for 16S rRNA gene sequencing and lipid analysis by gas chromatography-mass spectrometry. Alpha and beta diversity analyses and Procrustes randomization for associations were carried out. Results: Firmicutes, Proteobacteria, Bacteroidetes and Actinobacteria were the most abundant taxa. Variation in microbiome composition was greater between individuals than within ( Conclusion: Neonate gut microbiomes were unique to each neonate; respective metabolome profiles demonstrated generalizable temporal developments. The overall variability suggests potential interplay between influences including maternal breastmilk composition, amount consumed and living environment.

Indexed as

BreastfedFormula-fedFormula milkGastrointestinal microbiomeHuman milkInfantInfant gut microbiomeLipidomicMetaboliteMetabolome

Identifiers

PMID36950061
PMCPMC10025571
OpenAlexW4327518001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.