Evidence map›Paper›PMID 36949959›Full record

ArticleERJ open research2023

Molecular assessment of mycobacterial burden in the treatment of nontuberculous mycobacterial disease.

Huw C Ellis, Miriam F Moffatt, Colin Churchward, Leah Cuthbertson, William O C Cookson, Michael R Loebinger

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. IJTLD open · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Huw C EllisHost Defence Unit, Royal Brompton Hospital, London, UK.ORCID https://orcid.org/0000-0002-4351-1658
Miriam F MoffattImperial College London, London, UK.
Colin ChurchwardImperial College London, London, UK.
Leah CuthbertsonImperial College London, London, UK.ORCID https://orcid.org/0000-0002-9604-2269
William O C CooksonImperial College London, London, UK.
Michael R LoebingerHost Defence Unit, Royal Brompton Hospital, London, UK.
Imperial College London · GBRoyal Brompton Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Introduction: Nontuberculous pulmonary disease causes significant morbidity and mortality. Efforts to tackle infections are hampered by the lack of reliable biomarkers for diagnosis, assessment and prognostication. The aim of this study was to develop molecular assays capable of identifying and quantifying multiple nontuberculous mycobacterial (NTM) species and to examine their utility in following individual patients' clinical courses. Methods: DNA was extracted from 410 sputum samples obtained longitudinally from a cohort of 38 patients who were commencing treatment for either Results: The molecular assays had high Conclusion: The quantitative PCR assays developed in this study provide affordable, real-time and rapid measurement of NTM burden, with significant implications for prompt management decisions.

Identifiers

PMID36949959
PMCPMC10026000
OpenAlexW4308714221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.