ReviewFrontiers in cellular and infection microbiology2023
pH-activated antibiofilm strategies for controlling dental caries.
Review in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Biomimetic and Locally Active Drug Delivery Systems for the Oral Biofilm and Periodontal Pocket: Formulation Strategies, Mechanisms and Translational Perspectives.Pharmaceutics · 2026Review
- The association between parental oral health literacy, socio-demographic characteristic, patient factors and caries status of paediateric cancer patient: a cross-sectional study.Translational pediatrics · 2026Article
- Organ-on-chip (OoC) and nano-biomaterials: next generation of precision oral and dental healthcare research.Journal of nanobiotechnology · 2026Review
- Stimuli-responsive, antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration.International journal of oral science · 2026Review
- pH-responsive nanozymes: multifunctional platforms for biomedical catalysis toward clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Asiatic Acid Disrupts the Biofilm Virulence ofInternational journal of molecular sciences · 2025Article
- Review
- Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- Impact of Fasting on Granulocyte Chemotactic Protein-2 Chemokine and Lactate Dehydrogenase Enzyme Activity in the Development of Dental Caries.Sultan Qaboos University medical journal · 2025Observational
- Bioactive Composition of Tropical Flowers and Their Antioxidant and Antimicrobial Properties.Foods (Basel, Switzerland) · 2024Article
- Magnetic Field/Ultrasound-Responsive FeNanomaterials (Basel, Switzerland) · 2024Article
- Microbial Dynamics in Periodontal Regeneration: Understanding Microbiome Shifts and the Role of Antifouling and Bactericidal Materials: A Narrative Review.Current issues in molecular biology · 2024Review
- Towards Wiser Prescribing of Antibiotics in Dental Practice: What Pharmacists Want Dentists to Know.Dentistry journal · 2024Review
- Inhibitory Effects of Surface Pre-Reacted Glass Ionomer Filler Eluate onInternational journal of molecular sciences · 2024Article
- Antibacterial mechanism of areca nut essential oils againstFrontiers in cellular and infection microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental biofilms are highly assembled microbial communities surrounded by an extracellular matrix, which protects the resident microbes. The microbes, including commensal bacteria and opportunistic pathogens, coexist with each other to maintain relative balance under healthy conditions. However, under hostile conditions such as sugar intake and poor oral care, biofilms can generate excessive acids. Prolonged low pH in biofilm increases proportions of acidogenic and aciduric microbes, which breaks the ecological equilibrium and finally causes dental caries. Given the complexity of oral microenvironment, controlling the acidic biofilms using antimicrobials that are activated at low pH could be a desirable approach to control dental caries. Therefore, recent researches have focused on designing novel kinds of pH-activated strategies, including pH-responsive antimicrobial agents and pH-sensitive drug delivery systems. These agents exert antibacterial properties only under low pH conditions, so they are able to disrupt acidic biofilms without breaking the neutral microenvironment and biodiversity in the mouth. The mechanisms of low pH activation are mainly based on protonation and deprotonation reactions, acids labile linkages, and H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.