Evidence map›Paper›PMID 36949769›Full record

ArticleFrontiers in molecular neuroscience2023

Effects of glycogen synthase kinase-3β activity inhibition on cognitive, behavioral, and hippocampal ultrastructural deficits in adulthood associated with adolescent methamphetamine exposure.

Peng Yan, Jincen Liu, Haotian Ma, Yue Feng, Jingjing Cui, Yuying Bai, Xin Huang, Yongsheng Zhu, Shuguang Wei, Jianghua Lai

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Peng YanNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Jincen LiuNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Haotian MaNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Yue FengNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Jingjing CuiForensic Identification Institute, The Fourth People's Hospital of Yancheng, Yancheng, China.
Yuying BaiNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Xin HuangNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Yongsheng ZhuNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Shuguang WeiNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Jianghua LaiNHC Key Laboratory of Forensic Science, School of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Xi'an Jiaotong University · CNThe Fourth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Glycogen synthase kinase-3β (GSK3β) has been implicated in the maintenance of synaptic plasticity, memory process, and psychostimulant-induced behavioral effects. Hyperactive GSK3β in the Cornu Ammonis 1 (CA1) subregion of the dorsal hippocampus (DHP) was associated with adolescent methamphetamine (METH) exposure-induced behavioral and cognitive deficits in adulthood. This study aimed to evaluate the possible therapeutic effects of GSK3β inhibition in adulthood on adolescent METH exposure-induced long-term neurobiological deficits. Methods: Adolescent male mice were treated with METH from postnatal day (PND) 45-51. In adulthood, three intervention protocols (acute lithium chloride systemic administration, chronic lithium chloride systemic administration, and chronic SB216763 administration within CA1) were used for GSK3β activity inhibition. The effect of GSK3β intervention on cognition, behavior, and GSK3β activity and synaptic ultrastructure in the DHP CA1 subregion were detected in adulthood. Results: In adulthood, all three interventions reduced adolescent METH exposure-induced hyperactivity (PND97), while only chronic systemic and chronic within CA1 administration ameliorated the induced impairments in spatial (PND99), social (PND101) and object (PND103) recognition memory. In addition, although three interventions reversed the aberrant GSK3β activity in the DHP CA1 subregion (PND104), only chronic systemic and chronic within CA1 administration rescued adolescent METH exposure-induced synaptic ultrastructure changes in the DHP CA1 subregion (PND104) in adulthood. Conclusion: Rescuing synaptic ultrastructural abnormalities in the dHIP CA1 subregion by chronic administration of a GSK3β inhibitor may be a suitable therapeutic strategy for the treatment of behavioral and cognitive deficits in adulthood associated with adolescent METH abuse.

Indexed as

adolescenceCA1 – Cornu ammonis region 1glycogen synthase kinase-3β (GSK3β)hyperactivitymethamphetaminerecognition memory

Identifiers

PMID36949769
PMCPMC10025487
OpenAlexW4323316642

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read2
measurements read37
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.