Evidence map›Paper›PMID 36949755›Full record

ArticleiScience2023

LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells.

Juan Carlos Hernandez, Chia-Lin Chen, Tatsuya Machida, Dinesh Babu Uthaya Kumar, Stanley M Tahara, Jared Montana, Linda Sher, Jake Liang, Jae U Jung, Hidekazu Tsukamoto and 1 more

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Juan Carlos HernandezDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Chia-Lin ChenDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Tatsuya MachidaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Dinesh Babu Uthaya KumarDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Stanley M TaharaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Jared MontanaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Linda SherDepartment of Surgery, University of Southern California, Los Angeles, CA 90033, USA.
Jake LiangNIDDK, Bethesda, DC, USA.
Jae U JungDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Hidekazu TsukamotoDepartment of Pathology, University of Southern California, Los Angeles, CA 90033, USA.
Keigo MachidaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.
University of Southern California · USCalifornia State University, Channel Islands · USNational Yang Ming Chiao Tung University · TWVA Greater Los Angeles Healthcare System · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAPLOWITZ, NEIL · 1995 to 2020
$21.8M
NON-PARENCHYMAL LIVER CELL CORER24AA012885 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TSUKAMOTO, HIDEKAZU · 2001 to 2025
$8.1M
KSHV Epigenetic RegulationR01DE023926 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2024
$4.2M
NANOG-positive cancer stem cells in liver oncogenesis induced by alcohol and HCVR01AA025204 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACHIDA, KEIGO · 2017 to 2021
$1.9M
Nanog-positive cancer stem cells in and liver oncogenesis by alcohol and HCVR01AA018857 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACHIDA, KEIGO · 2009 to 2013
$1.8M
LncRNA with MSI2 and super-enhancer in liver cancer stem cells induced by alcoholR21AA025470 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACHIDA, KEIGO · 2018 to 2019
$444k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCI NIH HHS P30 CA014089NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA018857NIAAA NIH HHS R01 AA025204NIAAA NIH HHS R21 AA025470NIAAA NIH HHS R24 AA012885NIDCR NIH HHS R01 DE023926NIDDK NIH HHS P30 DK048522
6 · The paper itself

Abstract

Chemoresistance and plasticity of tumor-initiating stem-like cells (TICs) promote tumor recurrence and metastasis. The gut-originating endotoxin-TLR4-NANOG oncogenic axis is responsible for the genesis of TICs. This study investigated mechanisms as to how TICs arise through transcriptional, epigenetic, and post-transcriptional activation of oncogenic TLR4 pathways. Here, we expressed constitutively active TLR4 (

Indexed as

CancerCell biology

Identifiers

PMID36949755
PMCPMC10025994
OpenAlexW4321503007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.