Evidence map›Paper›PMID 36949749›Full record

ArticleBiophysical reports2023

Proteoliposomes reconstituted with human aquaporin-1 reveal novel single-ion-channel properties.

Sam W Henderson, Yoshitaka Nakayama, Murray L Whitelaw, John B Bruning, Peter A Anderson, Stephen D Tyerman, Sunita A Ramesh, Boris Martinac, Andrea J Yool

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sam W HendersonSchool of Biomedicine, University of Adelaide, Adelaide, SA 5005, Australia.
Yoshitaka NakayamaVictor Chang Cardiac Research Institute, Lowy Packer Building, Darlinghurst, NSW 2010, Australia.
Murray L WhitelawInstitute of Photonics and Advanced Sensing, The School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
John B BruningInstitute of Photonics and Advanced Sensing, The School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
Peter A AndersonSchool of Biological Sciences, Faculty of Science and Engineering, Flinders University, Adelaide, SA 5001, Australia.
Stephen D TyermanARC Centre of Excellence in Plant Energy Biology, School of Agriculture, Food and Wine & Waite Research Institute, University of Adelaide, Glen Osmond, SA 5064, Australia.
Sunita A RameshSchool of Biological Sciences, Faculty of Science and Engineering, Flinders University, Adelaide, SA 5001, Australia.
Boris MartinacVictor Chang Cardiac Research Institute, Lowy Packer Building, Darlinghurst, NSW 2010, Australia.
Andrea J YoolSchool of Biomedicine, University of Adelaide, Adelaide, SA 5005, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human aquaporin 1 (hAQP1) forms homotetrameric channels that facilitate fluxes of water and small solutes across cell membranes. In addition to water channel activity, hAQP1 displays non-selective monovalent cation-channel activity gated by intracellular cyclic GMP. Dual water and ion-channel activity of hAQP1, thought to regulate cell shape and volume, could offer a target for novel therapeutics relevant to controlling cancer cell invasiveness. This study probed properties of hAQP1 ion channels using proteoliposomes, which, unlike conventional cell-based systems such as

Identifiers

PMID36949749
PMCPMC10025285

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.