Evidence map›Paper›PMID 36949748›Full record

ArticleNon-coding RNA research2023

Regulating POLR3G by MicroRNA-26a-5p as a promising therapeutic target of lung cancer stemness and chemosensitivity.

Chang Ryul Park, Minhyeok Lee, Su Yel Lee, Daeun Kang, Se Jin Park, Dong Chul Lee, Han Koo, Young Gyu Park, Seong Lan Yu, In Beom Jeong and 4 more

Open access · goldAbstract read
In one paragraph

Article in Non-coding RNA research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. ncStem: a comprehensive resource of curated and predicted ncRNAs in cancer stemness.Database : the journal of biological databases and curation · 2024
    Article
  7. World journal of gastrointestinal oncology · 2024
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Chang Ryul ParkThoracic and Cardiovascular Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, 44033, Republic of Korea.
Minhyeok LeeDepartment of Internal Medicine, Konyang University Hospital, Daejeon, 35365, Republic of Korea.
Su Yel LeeMyunggok Research Institute for Medical Science, Konyang University, Daejeon, 35365, Republic of Korea.
Daeun KangDepartment of Internal Medicine, Konyang University Hospital, Daejeon, 35365, Republic of Korea.
Se Jin ParkDepartment of Internal Medicine, Konyang University Hospital, Daejeon, 35365, Republic of Korea.
Dong Chul LeeBiotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Han KooBiotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Young Gyu ParkDepartment of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Seong Lan YuMyunggok Research Institute for Medical Science, Konyang University, Daejeon, 35365, Republic of Korea.
In Beom JeongDepartment of Internal Medicine, Konyang University Hospital, Daejeon, 35365, Republic of Korea.
Sun Jung KwonDepartment of Internal Medicine, Konyang University Hospital, Daejeon, 35365, Republic of Korea.
Jaeku KangDepartment of Pharmacology, College of Medicine, Konyang University, Daejeon, 35365, Republic of Korea.
Eung Bae LeeDepartment of Thoracic Surgery, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Ji Woong SonDepartment of Internal Medicine, Konyang University Hospital, Daejeon, 35365, Republic of Korea.
Konyang University Hospital · KRKonyang University · KRKorea Research Institute of Bioscience and Biotechnology · KRUlsan College · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) identified in lung cancer exhibit resistance to chemotherapy, radiotherapy, and targeted therapy. Therefore, a technology for controlling CSCs is needed to overcome such resistance to cancer therapy. Various evidences about the association between epithelial-mesenchymal transition related transcriptomic alteration and acquisition of CSC phenotype have been proposed recently. Down-regulated miR-26a-5p is closely related to mesenchymal-like lung cancer cell lines. These findings suggest that miR-26a-5p might be involved in lung cancer stemness. RNA polymerase III subunit G (

Indexed as

Cancer stemnessChemosensitivityhsa-mir-26a-5pPOLR3G

Identifiers

PMID36949748
PMCPMC10025963
OpenAlexW4323663967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.