Evidence map›Paper›PMID 36949621›Full record

ArticlePsychiatry and clinical neurosciences2023

Are sleep disturbances a cause or consequence of autism spectrum disorder?

Takashi Yamada, Takeo Watanabe, Yuka Sasaki

Open access · bronzeAbstract read
In one paragraph

Article in Psychiatry and clinical neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Takashi YamadaDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0001-7342-4101
Takeo WatanabeDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, Rhode Island, USA.
Yuka SasakiDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, Rhode Island, USA.
Brown University · US

Funding

SYSTEMATIC PSYCHOPHYSICAL INVESTIGATION OF VISUAL LEARNINGR01EY019466 · NEI · BROWN UNIVERSITY · PI Takeo Watanabe · 2009 to 2026
$6.6M
Comprehensive frameworks of perceptual learningR01EY027841 · NEI · BROWN UNIVERSITY · PI Takeo Watanabe · 2018 to 2026
$3.2M
Roles of Non-REM and REM sleep in facilitating visual perceptual learningR01EY031705 · NEI · BROWN UNIVERSITY · PI SASAKI, YUKA · 2021 to 2024
$1.6M
NEI NIH HHS R01 EY019466NEI NIH HHS R01 EY027841NEI NIH HHS R01 EY031705
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core symptoms such as atypical social communication, stereotyped behaviors, and restricted interests. One of the comorbid symptoms of individuals with ASD is sleep disturbance. There are two major hypotheses regarding the neural mechanism underlying ASD, i.e., the excitation/inhibition (E/I) imbalance and the altered neuroplasticity hypotheses. However, the pathology of ASD remains unclear due to inconsistent research results. This paper argues that sleep is a confounding factor, thus, must be considered when examining the pathology of ASD because sleep plays an important role in modulating the E/I balance and neuroplasticity in the human brain. Investigation of the E/I balance and neuroplasticity during sleep might enhance our understanding of the neural mechanisms of ASD. It may also lead to the development of neurobiologically informed interventions to supplement existing psychosocial therapies.

Indexed as

Autism Spectrum DisorderBrainComorbidityHumansInhibition, PsychologicalSleepautism spectrum disordercortical excitabilityneural inhibitionneuronal plasticitysleep

Identifiers

PMID36949621
PMCPMC10871071
OpenAlexW4360600275

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.