Evidence map›Paper›PMID 36949521›Full record

ArticleOrphanet journal of rare diseases2023

The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis.

Aleksandra Kubiliute, Greta Gedvilaite, Alvita Vilkeviciute, Loresa Kriauciuniene, Akvile Bruzaite, Dalia Zaliuniene, Rasa Liutkeviciene

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecular Variants inInternational journal of women's health · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aleksandra KubiliuteMedical Faculty, Lithuanian University of Health Sciences, Medical Academy, Eiveniu Str. 2, 50161, Kaunas, Lithuania.
Greta GedvilaiteLaboratory of Ophthalmology, Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu Str. 2, 50161, Kaunas, Lithuania. greta.gedvilaite@lsmuni.lt.ORCID 0000-0001-7469-8825
Alvita VilkeviciuteLaboratory of Ophthalmology, Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu Str. 2, 50161, Kaunas, Lithuania.
Loresa KriauciunieneLaboratory of Ophthalmology, Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu Str. 2, 50161, Kaunas, Lithuania.
Akvile BruzaiteLaboratory of Ophthalmology, Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu Str. 2, 50161, Kaunas, Lithuania.
Dalia ZaliunieneDepartment of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2 Str, 50161, Kaunas, Lithuania.
Rasa LiutkevicieneLaboratory of Ophthalmology, Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu Str. 2, 50161, Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

THE

aimTo investigate the role of Sirtuin 1 (SIRT1) level and SIRT1 (rs3818292, rs3758391, rs7895833) gene polymorphisms in patients with optic neuritis (ON) and multiple sclerosis (MS).

methods79 patients with ON and 225 healthy subjects were included in the study. ON patients were divided into 2 subgroups: patients with MS (n = 30) and patients without MS (n = 43). 6 ON patients did not have sufficient data for MS diagnosis and were excluded from the subgroup analysis. DNA was extracted from peripheral blood leukocytes and genotyped by real-time polymerase chain reaction. Results were analysed using the program "IBM SPSS Statistics 27.0".

resultsWe discovered that SIRT1 rs3758391 was associated with a twofold increased odds of developing ON under the codominant (p = 0.007), dominant (p = 0.011), and over-dominant (p = 0.008) models. Also, it was associated with a threefold increased odds ofON with MS development under the dominant (p = 0.010), twofold increased odds under the over-dominant (p = 0.032) models and a 1.2-fold increased odds of ON with MS development (p = 0.015) under the additive model. We also discovered that the SIRT1 rs7895833 was significantly associated with a 2.5-fold increased odds of ON development under the codominant (p = 0.001), dominant (p = 0.006), and over-dominant (p < 0.001) models, and a fourfold increased odds of ON with MS development under the codominant (p < 0.001), dominant (p = 0.001), over-dominant (p < 0.001) models and with a twofold increased odds of ON with MS development (p = 0.013) under the additive genetic model. There was no association between SIRT1 levels and ON with/without MS development.

conclusionsSIRT1 rs3758391 and rs7895833 polymorphisms are associated with ON and ON with MS development.

Indexed as

Multiple SclerosisOptic NeuritisGenotypeHumansPolymorphism, Single NucleotideSirtuin 1SIRT1 protein, humanSirtuin 1Multiple sclerosisOptic neuritisSIRT1 ELISASIRT1 SNP

Identifiers

PMID36949521
PMCPMC10031967
OpenAlexW4360600292

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read118
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.