ArticleBMC pulmonary medicine2023
UMOYA: a prospective longitudinal cohort study to evaluate novel diagnostic tools and to assess long-term impact on lung health in South African children with presumptive pulmonary TB-a study protocol.
Article in BMC pulmonary medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis.PLoS medicine · 2025Pooled it
- Predicting radiological severity of pulmonary tuberculosis in children: an assessment of the WHO-criteria and novel prediction scores on an individual participant dataset.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Exploring non-sputum biosignatures for tuberculosis triage and diagnosis in children living with HIV.Expert review of molecular diagnostics · 2025Review
- Post-TB treatment completion experiences of children, adolescents, and caregivers from Cape Town.IJTLD open · 2025Article
- Article
- Article
- Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections.IJTLD open · 2025Article
- Lung life HRQoL measure: psychometric properties and initial data in presumptive TB.IJTLD open · 2025Article
- Anthropometric growth trajectories of children presenting with presumptive pulmonary TB.IJTLD open · 2025Article
- Health-related quality of life in children with presumptive TB.IJTLD open · 2024Article
- An item bank to measure health-related quality of life among young children (0-5-years-old) affected by respiratory illnesses - expert stakeholders and end-users from the Western Cape, South Africa.Health and quality of life outcomes · 2024Article
- Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment.Gut pathogens · 2024Article
- SARS-CoV-2 infection and pulmonary tuberculosis in children and adolescents: a case-control study.BMC infectious diseases · 2023Article
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Authors and funding
21 authors.
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Abstract
backgroundDespite a high paediatric tuberculosis (TB) burden globally, sensitive and specific diagnostic tools are lacking. In addition, no data exist on the impact of pulmonary TB on long-term child lung health in low- and middle-income countries. The prospective observational UMOYA study aims (1) to build a state-of-the-art clinical, radiological, and biological repository of well-characterised children with presumptive pulmonary TB as a platform for future studies to explore new emerging diagnostic tools and biomarkers for early diagnosis and treatment response; and (2) to investigate the short and long-term impact of pulmonary TB on lung health and quality of life in children.
methodsWe will recruit up to 600 children (0-13 years) with presumptive pulmonary TB and 100 healthy controls. Recruitment started in November 2017 and is expected to continue until May 2023. Sputum and non-sputum-based samples are collected at enrolment and during follow-up in TB cases and symptomatic controls. TB treatment is started by routine care services. Intensive follow-up for 6 months will allow for TB cases to retrospectively be classified according to international consensus clinical case definitions for TB. Long-term follow-up, including imaging, comprehensive assessment of lung function and quality of life questionnaires, are done yearly up to 4 years after recruitment. DISCUSSION: The UMOYA study will provide a unique platform to evaluate new emerging diagnostic tools and biomarkers for early diagnosis and treatment response and to investigate long-term outcomes of pulmonary TB and other respiratory events on lung health in children.
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