ArticleHealth and quality of life outcomes2023
What is the impact of post-COVID-19 syndrome on health-related quality of life and associated factors: a cross-sectional analysis.
Article in Health and quality of life outcomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Health-related quality of life in COVID-19 patients: a systematic review and meta-analysis of EQ-5D studies.Health and quality of life outcomes · 2025Pooled it
- Safety and Changes in Health-Related Quality of Life After Epidural Oxygen Injection for Long COVID/Post-COVID Syndrome: A Multicenter Retrospective Study.Journal of clinical medicine · 2026Article
- Health-related quality of life in IBD patients with long COVID under China's normalized COVID-19 management.BMC infectious diseases · 2026Article
- Neurocognitive and Neuropsychiatric Trajectories in a Post-COVID Cohort: A Descriptive Longitudinal Study.Neurology international · 2026Article
- Self-reported anxiety, depression, and health-related quality of life during two years following hospitalization for covid-19: a longitudinal study.Scientific reports · 2026Article
- Prevalence of Circulating Autoantibodies Against G-Protein-Coupled Receptors as Potential Biomarkers for Long COVID: Preliminary Investigations.International journal of molecular sciences · 2026Article
- Article
- Post-COVID-19 health-related quality of life in India: A systematic review and meta-analytic assessment of recovery outcomes.World journal of virology · 2025Article
- COVID-19-associated neurological and psychological manifestations.Nature reviews. Disease primers · 2025Review
- Health outcomes in hospitalised and non-hospitalised individuals after COVID-19, an observational, cross-sectional study.Communications medicine · 2025Article
- Lived Experiences of New-Onset Long Covid Pain and Its Impact on Health-Related Quality of Life. A Scoping Review of Current Evidence.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Impact of post-COVID-19 syndrome on quality of life and functionality in ethnically diverse and vulnerable populations in the Amazon.BMC infectious diseases · 2025Article
- Cross-sectional study of health impairment related to post COVID-19 condition among participants of a large population-based cohort in Germany.Scientific reports · 2025Article
- Long‑term physical and mental Health-Related Quality of Life in Italian patients post COVID-19 hospitalisation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Salivary cortisol in long COVID: a marker of broader stress system and circadian rhythm dysregulation.Frontiers in cellular and infection microbiology · 2025Article
- Quantifying the impact of post-acute sequelae of coronavirus on the cardiopulmonary endurance of athletes.Pulmonary circulation · 2024Article
- Cognitive and emotional predictors of quality of life and functioning after COVID-19.Annals of clinical and translational neurology · 2024Article
- Anxiety in Patients with Post-COVID Syndrome: Associated Factors.Psychology research and behavior management · 2024Article
- Effect of long COVID-19 syndrome on health-related quality of life: a cross-sectional study.Frontiers in psychology · 2024Article
- Connecting dots of long COVID-19 pathogenesis: a vagus nerve- hypothalamic-pituitary- adrenal-mitochondrial axis dysfunction.Frontiers in cellular and infection microbiology · 2024Review
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter the acute phase, symptoms or sequelae related to post-COVID-19 syndrome may persist for months. In a population of patients, previously hospitalized and not, followed up to 12 months after the acute infection, we aim to assess whether and to what extent post-COVID-19 syndrome may have an impact on health-related quality of life (HRQoL) and to investigate influencing factors.
methodsWe present the cross-sectional analysis of a prospective study, including patients referred to the post-COVID-19 service. Questionnaires and scales administered at 3, 6, 12 months were: Short-Form 36-item questionnaire (SF-36); Visual Analogue Scale of the EQ5D (EQ-VAS); in a subgroup, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II) and Pittsburgh Sleep Quality Index (PSQI). Linear regression models were fitted to identify factors associated with HRQoL.
resultsWe considered the first assessment of each participant (n = 572). The mean scores in SF-36 and in EQ-VAS were significantly lower than the Italian normative values and remained stable over time, except the mental components score (MCS) of the SF-36 and EQ-VAS which resulted in lower ratings at the last observations. Female gender, presence of comorbidities, and corticosteroids treatment during acute COVID-19, were associated with lower scores in SF-36 and EQ-VAS; patients previously hospitalized (54%) reported higher MCS. Alterations in BAI, BDI-II, and PSQI (n = 265)were associated with lower ratings in SF-36 and EQ-VAS.
conclusionsThis study provides evidence of a significantly bad perception of health status among persons with post-COVID-19 syndrome, associated with female gender and, indirectly, with disease severity. In case of anxious-depressive symptoms and sleep disorders, a worse HRQoL was also reported. A systematic monitoring of these aspects is recommended to properly manage the post-COVID-19 period.
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