ArticleBMC nephrology2023
Subclinical thyroid dysfunction and chronic kidney disease: a nationwide population-based study.
Article in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association between hypothyroidism, levothyroxine replacement and kidney function outcomes: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Association between hypothyroidism and risk of chronic kidney disease: evidence from a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Dynamic patterns of thyroid hormones and incident chronic kidney disease: evidence from 18 years of follow-up in the Tehran Thyroid Study.Journal of endocrinological investigation · 2026Article
- Association Between Chronic Kidney Disease and Subclinical Hypothyroidism Categorized by Hypertension Status.Diseases (Basel, Switzerland) · 2026Article
- The long-overlooked effect of hypothyroidism on the global burden of non-communicable diseases.Nature reviews. Endocrinology · 2026Article
- Kidney diseases and the thyroid: interactions and consequences.Nature reviews. Endocrinology · 2026Review
- Endocrine disorders linked to chronic kidney disease: Mechanisms and clinical implications.World journal of nephrology · 2026Review
- Levothyroxine treatment for subclinical hypothyroidism and risk of adverse renal outcomes: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- Role of subclinical hypothyroidism on kidney damage in children with obesity.International journal of obesity (2005) · 2025Article
- Estimation of kidney function in Graves' disease using creatinine and cystatin C.Endocrine connections · 2025Article
- The association of thyroid hormone levels and incidence of chronic kidney disease: the Tehran thyroid study (TTS).Thyroid research · 2025Article
- Analysis of risk factors for abnormal renal function in patients with gout in Southwest China: a cross-sectional study.Rheumatology advances in practice · 2025Article
- Assessment of Renal Function in Patients with Chronic Kidney Disease with and without Hypothyroidism.Ethiopian journal of health sciences · 2025Article
- Interrelationship between thyroid hormones and reduced renal function, a review article.Thyroid research · 2024Article
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Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) has a significant impact on global health. Studies have shown that subclinical thyroid dysfunction may be related to CKD, but the association between subclinical thyroid dysfunction and CKD in the general population is unclear. We aimed to evaluate the risk of CKD according to thyroid function status in a large cohort.
methodsWe analyzed data from a nationwide, population-based, cross-sectional survey (KNHANES VI). A total of 3,257 participants aged ≥ 19 years who underwent thyroid and kidney function assessments were included in this study. CKD was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m
resultsOverall, 6.7% of the participants had CKD. There were no significant differences in thyroid-stimulating hormone and free thyroxine levels between the groups with and without CKD. The proportion of participants with CKD was significantly different among the thyroid function status groups (p = 0.012) and tended to increase significantly in the following order: subclinical hyperthyroidism (1.5%), euthyroidism (6.6%), and subclinical hypothyroidism (12.6%) (p for trend < 0.001). Subclinical hypothyroidism was a significant risk factor for CKD, even after adjusting for sex, age, household income, education, smoking, alcohol consumption, walking activity, abdominal obesity, hypertension, low high-density lipoprotein cholesterol, elevated triglycerides, hyperglycemia, free thyroxine, and thyroid-peroxidase anibody (odds ratio 2.161, 95% confidence interval 1.032-4.527, p = 0.041).
conclusionSubclinical hypothyroidism is an independent predictor of CKD in the general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.