ArticleScience China. Life sciences2023
Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis.
Article in Science China. Life sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Nematode-trapping devices of Arthrobotrys oligospora is an iron storage system mediated by elevated temperatures.FEMS microbiology ecology · 2026Article
- Novel Anthraquinone Chlorination Contributes to Pigmentation and ATP Formation in Thermomyces dupontii.Microbial biotechnology · 2025Article
- Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora.Journal of advanced research · 2025Article
- Thermophilic fungus uses anthraquinones to modulate ferrous excretion, sterol-mediated endocytosis, and iron storage in response to cold stress.Microbial biotechnology · 2024Article
- Characterizing the Role ofMicroorganisms · 2024Article
- Gene fusion and functional diversification ofMycology · 2024Article
- Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress.Heliyon · 2023Article
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12 authors at 3 institutions in 1 country.
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Abstract
The discovery of biological activities of natural products plays a vital part in drug development. The mechanism by which organisms respond to temperature changes via biosynthesis of natural products remained largely cryptic. A thermophilic fungus under cold stress turned black and accumulated a polyketide metabolite 1 and lipid mass. Deficiency in 1 caused melanin loss and accumulated extra lipid mass, unexpectedly leading to seriously damaged mitochondria diagnostic for ferroptosis. Further analysis revealed that lipid mass induced by cold stress intensively increased ferroptosis risk and 1 functioned as cell wall reinforcer against mass lipid accumulation and as reactive oxygen species scavenger against lipid peroxidation. We also found that melanin in mice lowered lipid level but enhanced animal resistance to cold stress. Treatment with melanin precursors significantly increased mouse cell survival rate under cold stress. Our results unveiled a metabolite-lipid-ferroptosis-cold relationship, which provided mechanistic insights into the functions of most common metabolites and into diseases related to cold stress. These findings opened a perspective for developing anti-cold and anti-ferroptosis therapeutics and agents.
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