Evidence map›Paper›PMID 36949197›Full record

ArticleNature2023

From primordial clocks to circadian oscillators.

Warintra Pitsawong, Ricardo A P Pádua, Timothy Grant, Marc Hoemberger, Renee Otten, Niels Bradshaw, Nikolaus Grigorieff, Dorothee Kern

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Ecosystem relocation on Snowball Earth: Polar-alpine ancestry of the extant surface biosphere?Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. The cyanobacterial circadian clock.Npj biological timing and sleep · 2025
    Review
  14. Article
  15. Article
  16. Temperature-dependent fold-switching mechanism of the circadian clock protein KaiB.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. The inner workings of an ancient biological clock.Trends in biochemical sciences · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Warintra Pitsawong *Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA, USA.
Ricardo A P Pádua *Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA, USA.
Timothy Grant *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Marc HoembergerHoward Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA, USA.ORCID http://orcid.org/0000-0003-2515-1094
Renee OttenHoward Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA, USA.ORCID http://orcid.org/0000-0001-7342-6131
Niels BradshawDepartment of Biochemistry, Brandeis University, Waltham, MA, USA.
Nikolaus GrigorieffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-1506-909X
Dorothee KernHoward Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA, USA. dkern@brandeis.edu.ORCID http://orcid.org/0000-0002-7631-8328

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM124169-01
6 · The paper itself

Abstract

Circadian rhythms play an essential part in many biological processes, and only three prokaryotic proteins are required to constitute a true post-translational circadian oscillator

Indexed as

Bacterial ProteinsCircadian ClocksCircadian RhythmRhodobacter sphaeroidesAdenosine DiphosphateAdenosine TriphosphateAllosteric RegulationCryoelectron MicroscopyCrystallography, X-RayKineticsPhosphorylationProtein ConformationProtein FoldingAdenosine DiphosphateAdenosine TriphosphateBacterial Proteins

Identifiers

PMID36949197
PMCPMC10076222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.