ArticleNature2023
Gut enterochromaffin cells drive visceral pain and anxiety.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
38.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- P INK1/PARKIN mitophagy: a potential regulator of mitochondrial homeostasis in functional dyspepsia.Frontiers in physiology · 2026Pooled it
- Dissociable control of depression and visceral pain by the pICNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Unraveling the gut microbiota-brain axis: Mechanisms, pathophysiology, and therapeutic opportunities.iScience · 2026Review
- From Epithelial Sensing to Visceral Pain: Neuropod and Enterochromaffin Cells in Gut Neuroepithelial Circuits.International journal of molecular sciences · 2026Review
- A Combined Colon Organoid-Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease.Phytotherapy research : PTR · 2026Article
- Short-chain fatty acid-producing psychobiotics in mood disorders: mechanistic insights into the microbiota-gut-brain axis.Clinical nutrition research · 2026Article
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
- Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes.Cellular & molecular biology letters · 2026Review
- The gut microbiome shapes social behaviour across animal species.Nature reviews. Microbiology · 2026Review
- Fundamentals of Neurogastroenterology: Basic Science.Gastroenterology · 2026Review
- Article
- Gut microbiota and pancreatic cancer: tumorigenesis, progression, and clinical applications.Cancer biology & medicine · 2026Review
- DSS Colitis Model: Traps, Tricks, and Reporting Recommendations.Biomedicines · 2026Review
- GABAExperimental physiology · 2026Article
- Molecular mechanisms and therapeutic potential of tryptophan metabolism in gut-brain signaling transduction: a narrative review.Journal of neuroinflammation · 2026Review
- Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment.Nature reviews. Gastroenterology & hepatology · 2026Review
- Gut-brain communication: types of sensory nerves and mechanisms of activation.Nature reviews. Gastroenterology & hepatology · 2026Review
- Mechanisms and clinical implications of gut-brain interactions.The Journal of clinical investigation · 2026Review
- Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
James R Bayrer *Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. james.bayrer@ucsf.edu.ORCID http://orcid.org/0000-0002-7534-3329
Joel Castro *College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia.
Archana VenkataramanDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.
Kouki K TouharaDepartment of Physiology, University of California, San Francisco, CA, USA.
Nathan D RossenDepartment of Physiology, University of California, San Francisco, CA, USA.
Ryan D MorrieDepartment of Physiology, University of California, San Francisco, CA, USA.
Jessica MaddernCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia.
Aenea HendryCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia.
Kristina N BravermanDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Sonia Garcia-CaraballoCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia.
Gudrun SchoberCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia.
Mariana BrizuelaCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia.
Fernanda M Castro NavarroDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.
Carla Bueno-SilvaDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Holly A IngrahamDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. holly.ingraham@ucsf.edu.ORCID http://orcid.org/0000-0001-6739-2967
Stuart M BrierleyCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia. stuart.brierley@sahmri.com.ORCID http://orcid.org/0000-0002-2527-2905
David JuliusDepartment of Physiology, University of California, San Francisco, CA, USA. david.julius@ucsf.edu.ORCID http://orcid.org/0000-0002-6365-4867
University of California, San Francisco · USSouth Australian Health and Medical Research Institute · AUJohnson & Johnson (United States) · US
Funding
Natural products as probes of the pain pathwayR35NS105038 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIUS, DAVID · 2018 to 2025
$9.0MTRAINING PROGRAM IN PEDIATRIC GASTROENTEROLOGY/NUTRITIONT32DK007762 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Bayrer · 1998 to 2026
$7.3MDissecting a hormone-responsive processor for female activity and repetitive behaviorR01DK121657 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2020 to 2024
$2.9MResubmission of Diversity SupplementR01DK128346 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BAYRER, JAMES · 2021 to 2025
$2.8MMapping gut-spinal cord connections in visceral painU01NS113869 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A., JULIUS, DAVID · 2019 to 2021
$2.4MArcuate ERa Signaling in Central Control of Female Bone MetabolismR01AG062331 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2019 to 2023
$2.3MUncovering the role of LRH-1 in enteroendocrine cell development and ‘gut-brain’ communicationR03DK121061 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BAYRER, JAMES · 2019 to 2020
$241kNIA NIH HHS R01 AG062331NIDDK NIH HHS R01 DK121657NIDDK NIH HHS R01 DK128346NIDDK NIH HHS R03 DK121061NIDDK NIH HHS T32 DK007762NINDS NIH HHS R35 NS105038NINDS NIH HHS U01 NS113869
Abstract
Gastrointestinal (GI) discomfort is a hallmark of most gut disorders and represents an important component of chronic visceral pain
Indexed as
AnxietyEnterochromaffin CellsVisceral PainDigestive SystemFemaleHumansInflammationIrritable Bowel SyndromeMaleReproducibility of ResultsSerotoninSex CharacteristicsSerotonin
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.