Evidence map›Paper›PMID 36948960›Full record

ArticleTransplantation proceedings2023

Heart Transplantation from COVID-19-Positive Donors: A Word of Caution.

Alejandra Castro-Varela, Carlos Gallego-Navarro, Eric Bhaimia, Aanchal Gupta, Philip J Spencer, Richard C Daly, Alfredo L Clavell, Gustavo L Knop, Joseph J Maleszewski, Mauricio A Villavicencio and 1 more

Abstract read
In one paragraph

Article in Transplantation proceedings, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alejandra Castro-VarelaDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Carlos Gallego-NavarroDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Eric BhaimiaDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Aanchal GuptaDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Philip J SpencerDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Richard C DalyDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Alfredo L ClavellDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Gustavo L KnopDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Joseph J MaleszewskiDepartment of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota.
Mauricio A VillavicencioDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Nathan W CumminsDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: cummins.nathan@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the COVID-19 pandemic, efforts to maintain solid-organ transplantation have continued, including the use of SARS-CoV-2-positive heart donors.

methodsWe present our institution's initial experience with SARS-CoV-2-positive heart donors. All donors met our institution's Transplant Center criteria, including a negative bronchoalveolar lavage polymerase chain reaction result. All but 1 patient received postexposure prophylaxis with anti-spike monoclonal antibody therapy, remdesivir, or both.

resultsA total of 6 patients received a heart transplant from a SARS-CoV-2-positive donor. One heart transplant was complicated by catastrophic secondary graft dysfunction requiring venoarterial extracorporeal membrane oxygenation and retransplant. The remaining 5 patients did well postoperatively and were discharged from the hospital. None of the patients had evidence of COVID-19 infection after surgery.

conclusionHeart transplants from SARS-CoV-2 polymerase chain reaction-positive donors are feasible and safe with adequate screening and postexposure prophylaxis.

Indexed as

COVID-19Heart TransplantationHumansPandemicsSARS-CoV-2Tissue Donors

Identifiers

PMID36948960
PMCPMC9981670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.