ArticleBiological psychiatry2024
Tractography-Based Modeling Explains Treatment Outcomes in Patients Undergoing Deep Brain Stimulation for Obsessive-Compulsive Disorder.
Article in Biological psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Effectiveness of Deep Brain Stimulation for Treatment-Resistant OCD: Systematic Review of Anatomical Targets and Meta-Analysis of Randomized and Non-Randomized Studies.Brain sciences · 2026Review
- Deep Brain Stimulation Response Circuits in Obsessive-Compulsive Disorder.Biological psychiatry · 2026Review
- Deep brain stimulation for obsessive-compulsive disorder: evolution of tractography-based targeting.Journal of neurosurgery · 2026Article
- A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity.Translational psychiatry · 2025Article
- From adaptive deep brain stimulation to adaptive circuit targeting.Nature reviews. Neurology · 2025Review
- Deconstructing a common pathway concept for Deep Brain Stimulation in the case of Obsessive-Compulsive Disorder.Molecular psychiatry · 2025Article
- Shaping the Future of Psychiatric Neurosurgery: From Connectomic Precision to Technological Integration.Brain sciences · 2025Review
- Reciprocal projections between the globus pallidus externa and cortex span motor and nonmotor regions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Subthalamic Deep Brain Stimulation: Mapping Non-Motor Outcomes to Structural Connections.Human brain mapping · 2025Article
- Effective deep brain stimulation for obsessive-compulsive disorder after failed anterior capsulotomy: illustrative cases.Journal of neurosurgery. Case lessons · 2024Article
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal Stimulation Sites.Biological psychiatry · 2024Article
- Modeling the volume of tissue activated in deep brain stimulation and its clinical influence: a review.Frontiers in human neuroscience · 2024Review
- Directional electrodes in deep brain stimulation: Results of a survey by the European Association of Neurosurgical Societies (EANS).Brain & spine · 2024Article
- Tractography-based DBS lead repositioning improves outcome in refractory OCD and depression.Frontiers in human neuroscience · 2023Article
- RapidParc: A global-context transformer for parallel, accurate, and lesion-robust tractogram parcellation.Imaging neuroscience (Cambridge, Mass.)Article
- Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment.Brain and neuroscience advancesReview
Corrections and comments
- Erratum issuedErratum.2024
Authors and funding
13 authors.
Funding
Abstract
backgroundDeep brain stimulation (DBS) is an established and expanding therapy for treatment-refractory obsessive-compulsive disorder. Previous work has suggested that a white matter circuit providing hyperdirect input from the dorsal cingulate and ventrolateral prefrontal regions to the subthalamic nucleus could be an effective neuromodulatory target.
methodsWe tested this concept by attempting to retrospectively explain through predictive modeling the ranks of clinical improvement as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) in 10 patients with obsessive-compulsive disorder who underwent DBS to the ventral anterior limb of internal capsule with subsequent programming uninformed by the putative target tract.
resultsRank predictions were carried out using the tract model by a team that was completely uninvolved in DBS planning and programming. Predicted Y-BOCS improvement ranks significantly correlated with actual Y-BOCS improvement ranks at the 6-month follow-up (r = 0.75, p = .013). Predicted score improvements correlated with actual Y-BOCS score improvements (r = 0.72, p = .018).
conclusionsHere, we provide data in a first-of-its-kind report suggesting that normative tractography-based modeling can blindly predict treatment response in DBS for obsessive-compulsive disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.